C-H Bond Activation in Organic Synthesis

ISBN-13: 9781138894112 / Angielski / Miękka / 2017

Opis

C–H activation involves any of a wide range of techniques, often using catalysts in which a carbon to hydrogen covalent bond of an organic compound is cleaved to replace the hydrogen with a functional group. C–H Activation for functionalization is the state of the art in organic chemistry. It enables chemists to carry out reactions in the most environmentally friendly fashion with the least contamination of by-products. Written by an author experienced in this rapidly developing the field, this book covers C–H activation by a variety of catalysts.

Spis treści

Introduction. Radical-Mediated C—H Bond Activation. Pd-Catalyzed C—H Functionalization. Rhodium-Catalyzed C—H Activation. Nickel-Catalyzed C—H Activation. Iron-Catalyzed C—H Activation. Copper-Mediated C—H Activation. Cobalt-Catalyzed C—H Activation. Fluorination and Trifluoromethylation of Arenes and Heteroarenes via C—H Activation. C—H Activation of Heteroaromatics.

O autorze

Jie Jack Li earned his PhD in organic chemistry in 1995 at Indiana University. After a stint as a postdoctoral fellow MIT, he worked as a medicinal chemist at Pfizer and Bristol-Myers Squibb from 1997 to 2012. Since then he has been an associate professor of chemistry at the University of San Francisco teaching organic and medicinal chemistry. He has published 23 books ranging from organic and medicinal chemistry, to the history of drug discovery.