1. Overview of BTK pathway 2. Overview of BTK inhibitors and their clinical utility [1st gen, 2nd gen] 3. Mechanisms of therapy resistance in cancer cells 4. BTK inhibitors in paclitaxel and docetaxel resistance 5. BTK inhibitors in Platinum resistance 6. BTK inhibitors in BRAF resistance 7. BTK inhibitors in radio-resistance 8. Ibrutinib beyond BTK inhibition and role in immunotherapy resistance 9. Novel BTK inhibitors and future perspectives