Bronchoalveolar Mast Cells and Asthma

ISBN-13: 9781447114604 / Angielski / Miękka / 2011 / 84 str.

B. N. C. Hudspith

Opis

The publication of Bronchoalveolar Mast Cells and Asthma marks the emergence of The Bloomsbury Series in Clinical Science, an important and novel series that will highlight, review and record major areas of research, development and practice in the field of clinical science. A number of other monographs are now in an advanced state of preparation and their release will establish not only their individual significance but that of the series as a whole. My thanks are due to the Editorial Board who have provided the ideas and selected the authors and whose continuing enthu- siasm is so vital to the success of the series. Michael Jackson of Springer-Verlag merits special thanks for initially realising the potential of such a series and then guiding us all through to the time of its launch. Marianne Williams has supported us all and has provided the important link between Editorial Board and pub- lisher. The author of this first publication, Kevin Flint, was tragically killed during its preparation, and we hope that the book will serve as a tribute to the memory of Kevin for all who were lucky enough to know him. Barry Hudspith has been of enormous help in finalising the work and in shaping the form of the book.

Spis treści

1 Mast Cells and the Allergic Response.- Mast Cell Activation and Mediator Release.- Mast Cell Activation.- Mast Cell Mediators.- Preformed Mediators.- Newly Generated Mediators.- Mast Cell Mediators and Their Antagonists In Vivo and In Vitro.- 2 Mast Cell Heterogeneity.- Morphological Heterogeneity.- Ontogeny of Mast Cells.- Functional Differences.- 3 Superficial Mast Cells and the Asthmatic Response.- Bronchoalveolar Lavage Technique.- Human Bronchoalveolar and Dispersed Lung Mast Cells.- Morphological Heterogeneity of Human Lung Mast Cells.- Human Lung Mast Cells.- Mediator Release from Human Bronchoalveolar Mast Cells.- 4 Some Functional Properties of Human Bronchoalveolar and Dispersed Lung Mast Cells.- Histamine Content and IgE-Dependent Histamine Release.- The Effect of Anti-allergic Compounds.- Disodium Cromoglycate.- Nedocromil Sodium.- Salbutamol.- Theophylline.- 5 Hyperosmolar Histamine Release from Human Lung Mast Cells: Its Relevance to Exercise-Induced Asthma.- Mannitol-Induced Histamine Release.- Basophils.- Lung Mast Cells.- Increased Extracellular Osmolarity and Histamine Release.- 6 Newly Generated Mediators from Human Lung Mast Cells.- Mediator Release from Human Dispersed Lung Mast Cells.- Mediator Release from Human Bronchoalveolar Cells.- Newly Generated Mediators of Immediate Hypersensitivity.- Prostaglandins and Thromboxanes.- Prostaglandin D2.- Prostaglandin F2?.- Prostaglandin E2.- Prostacyclin (PGI2).- Slow Reacting Substances and the Leukotrienes.- SRS-A Production.- Biological Effects.- Platelet Activating Factor.- 7 Bronchoalveolar Mast Cells and Asthma.- Extrinsic Asthma.- Intrinsic Asthma.- Effect of Corticosteroids.