Breast Cancer: Scientific and Clinical Progress: Proceedings of the Biennial Conference for the International Association of Breast Cancer Research, M

ISBN-13: 9780898383874 / Angielski / Twarda / 1988 / 389 str.

International Association for Breast Cancer Research; Marvin A. Rich; Jean Carol Hager

Opis

Effective control of breast cancer depends on three types of research accomplishment -- understanding the disease's origins and progression: successfully applying this knowledge to methods of detection, diagnosis and treatment: and finding ways to make these advances truly available to the public as effectively as possible. The significant progress that is occurring across this entire spectrum of pioneering investigation is reflected in these proceedings of the 1987 biennial conference of the International Association for Breast Cancer Research. The first section of the book focuses on oncogenes and chemical effectors that may play key roles in early cell transformation leading to breast cancer. Research discussed includes identification of specific oncogenes which appear to be involved in the disease, study of their activation and expression, examination of the biological effects of various growth factors isolated from breast cancer cell lines, and investigation of the molecular mechanisms by which estrogens promote and stimulate growth of breast cancers. The second group of chapters deals with several other complex factors and phenomena which may influence tumor formation in the breast, for example, expression of abnormalities by fibroblasts, disruption of epithelial-mesenchymal interactions, and loss of ability nili to synthesize normal basal lamina resulting in alterations in the extracellular matrix. Clarification of the processes of normal mammary gland development and differentiation is central to much of this work.

Spis treści

I Oncogenes/Growth Factors—Their Role in Breast Cancer.- 1. An Analysis of Three Proto-Oncogenes in Primary Human Breast Tumor DNAs: The c-mos, the C-erbB-2 and the Epidermal Growth Factor Receptor Genes.- 2. Proviral Activation of Potential Oncogenes in Tumors Induced by Mouse Mammary Tumor Virus.- 3. Quantitative and Qualitative Changes in Oncogene Expression During Carcinogenesis.- 4. Mammary Tumor-Associated Growth Factors: Origins and Possible Functions.- 5. The Oestrogen-Induced pS2 Gene and the Oestrogen Receptor in Breast Cancer.- 6. Workshop on Oncogenes and Chemical Effectors of Neoplastic Transformation.- II Mammary Gland Development, Differentiation and Pathology in Relationship to Malignancy.- 7. Immunological Markers in the Study of the Development of the Mouse Mammary Gland and Its Tumors.- 8. Cloning the Polymorphic Gene for the Mammary Mucin Abnormally Glycosylated in Carcinomas.- 9. Regulation of Tissue-Specific Gene Expression in the Mammary Gland: The Role of the Extracellular Matrix.- 10. The Possible Role of Abnormal Fibroblasts in the Pathogenesis of Breast Cancer.- 11. Myoepithelial and Endocrine Differentiation in Breast Carcinoma.- 12. Human Monoclonal Antibodies Directed Against Viral Antigens.- 13. Cytotoxic Effector Mechanisms Involved in the Immunity Against Mammary Tumors.- 14. Mesenchymal-Epithelial Interactions in Normal and Malignant Mammary Cells.- 15. Breast Cancer Differentiation and Progression: Analysis with Monoclonal Antibodies and Flow Cytometry.- III New Developments in Clinical Applications.- 16. Mammary Epithelial Antigens as a Breakthrough in Breast Cancer Research: Now Where to?.- 17. CA15-3 and Related Antigens as Serum Markers for Monitoring Breast Cancer.- 18. Nuclear DNA Content and Prognosis in Breast Cancer.- 19. Perspectives for the Clinical Use of Aromatase Inhibitors.- 20. Monoclonal Antibodies for Improved Evaluation of Breast Cancer Prognosis.- 21. Hormone Receptors and Interactions Workshop Summary.- IV New Perspectives in the Prevention and Control of Breast Cancer.- 22. The Role of Diet in the Etiology and Causation of Breast Cancer.- 23. Is Primary Prevention of Breast Cancer Achievable?.- 24. Large Scale Screening Programs in Breast Cancer Prevention.- 25. Successful Research Findings: What Comes Next?.