Breast Cancer Immunodiagnosis and Immunotherapy

ISBN-13: 9781475712988 / Angielski / Miękka / 2012 / 259 str.

Roberto Ceriani

Opis

The convening of the 3rd International Workshop on Monoclonal Antibodies and Breast Cancer had the character of a self-search exercise. After almost a decade of research in the basic and applied aspects of the use of serological means to diagnose and possibly treat breast cancer several milestones have been reached. Among them a clear understanding of immunopathological use and limitations of monoclonal antibodies against breast epithelium, the complete development and clinical use of immunoassays for circulating breast epithelial antigens, the striking advances in the diagnostic use of monoclonal antibodies to estrogen and progesterone receptor proteins and the first communications on proposed immunotherapeutic use of different conjugates of anti-breast antibodies. New areas of investigation have developed in our field, some which are reaching a full blossom while others are still facing obstacles and at times a re-definition of their goals and objectives. These meetings have acted in a way as a clearing house and have permitted their attendees to derive predictions that have helped shape future research and fine-tune objectives. But above all, the re-evaluation of past research at these Workshops and the renewed excitement brought to them by new information has helped generate a momentum and enthusiasm that assures for the future large scientific gains.

Spis treści

Session I.- The Potential of Synthetic Tumor — Associated Glycoconjugates S-TAGs) for Generating Monoclonal Antibodies for Breast Cancer Imaging and for Speific Immunotherapy.- Extracellular Keratins: An Update.- Preclinical Evaluation of MoAbs Mc5 and BrEl.- The Use of Human Monoclonal Antibodies to Identify and Isolate Breast Tumor Associated Antigens.- Clinical and Molecular Investigations of the DF3 Breast Cancer — Associated Antigen.- An Assay For Cryptic Tumor Antigens in Sera of Women With Breast Cancer.- Session II.- Biosynthesis of the Cell Surface Sialomucin From Ascites 13762 Rat Mammary Adenocarcinoma Cels: Intracellular Maturation.- Epithelial Mucin Antibodies and Their Epitopes: Core Protein Epitopes of a Polymorphic Epithelial Mucin (PEM).- Cell Heterogeneity and Complexity of Breast Epithelial Surface Antigens Expression and MoAb Therapy.- The Oncogenic Potential of Membrane Receptor Proteins Encoded by Members of the Human erbB Proto-Oncogene Family.- Session III.- Estrogen and Progesterone Receptor Analysis and Action in Breast Cancer.- Monoclonal Antibodies Against Steroid Receptors and Steroid-Induced Proteins.- Ten Year Survival Patterns in Primary Breast Cancers Compared to Hormone Receptor Antigen Detection by Monoclonal Antibodies.- Significance of Steroid Receptor Immunoassay in Breast Cancer.- H23 Monoclonal Antibodies Recognize a Breast Tumor Associated Antigen: Clinical and Molecular Studies.- Complementation of Monoclonal Antibodies DF3 and B72.3 in Reactivity to Breast Cancer.- Differential Expression of DF3 Antigen Between Papillary Carci — nomas and Benign Papillary Lesions of the Breast.- Session IV.- Potentiation of Anti-Tumor Efficacy Resulting From the Combined Administration of Interferon and ofan Anti-Breast Epithelial Monoclonal Antibody in the Treatment of Breast Cancer Xenografts.- Immunolymphscintigraphy with BCD-F9 Monoclonal Antibody and its F(ab)’2 Fragments for the Preoperative Staging of Breast Cancers.- Reaction of Antibodies to Human Milk Fat Globule (HMFG) With Synthetic Peptides.- Individually Specified Drug Immunoconjugates in Cancer Treatment.- A Phase I Study of the Anti-Breast Cancer Immunotoxin 2609 MAB-rRA Given by Continuous Infusion.- In Vivo Studies of Radiolabeled Monoclonal Antibodies MC5 and KC4 Human Breast Cancer.- Contributors.