Brain and Heart CrossTalk

ISBN-13: 9789811524967 / Angielski / Twarda / 2020 / 130 str.

Hemanshu Prabhakar; Indu Kapoor

Spis treści

I. Introduction

II. Neurophysiology and Cardiovascular system

a. Organization of Medullary nuclei for regulation of the CVS

i. Nucleus tractussolitarius

ii. Rostral Ventro lateral medullary region

iii. Caudal Ventro lateral medullary region

iv. Nucleus accumbens

b. Organization of spinal and peripheral neural connection

i. Intermedio-Lateral horn

ii. Para-vertebral sympathetic chain 

iii. Cranial and caudal parasympathetic outflow

c. Integrated neural regulation of CVS 

i. Negative feedback mechanism as primary regulatory mechanism

ii. Receptors

iii. Afferent

iv. centre

v. efferents

d. Interaction of medullary-spinal CVS centre with neural centres controlling other organ systems.

e. Cardiovascular reflexes

III. Normal physiology of Circulatory System

1. Organization of cardiovascular system 

2. Determinants of pump function of heart

3. Features of arterial, venous and capillary circulation 

4. Biophysics of Cardiovascular system

5. Regulation of blood pressure

6. Regulation of circulatory blood volume 

7. Normal values physiological values and ranges of various parameters like HR, CO, BP etc.

IV. Brain – Heart crosstalk

1. Stress-related cardiomyopathy syndromes in anaesthesia and intensive care

2. Pathophysiology of  Neurogenic stress cardiomyopathy

3. Neurocardiogenic injury and cardioregulatory centers

4. Neurocardiogenic injury and Polymorphisms of adrenergic receptors

5. Monitoring for Neurogenic stress cardiomyopathy

6. Proposed treatment for Neurogenic stress cardiomyopathy

O autorze

Dr. Hemanshu Prabhakar MBBS, MD, PhD is currently working as a Professor at the Department of Neuroanaesthesiology and Critical Care at the All India Institute of Medical Sciences, New Delhi. He has research experience spanning over 20 years, and is a member of numerous national and international societies. His extensive research in the field of neuroanaesthesia and critical care has been published in various national and international journals. Dr.Prabhakar is an eminent author and written several books. He received the AIIMS Excellence Award 2012 for his contributions to academia. He features in the Limca Book of Records 2019.

Dr. Indu Kapoor holds an MBBS from the Lady Hardinge Medical College, and an MD in Anesthesiology from University College of Medical Sciences Delhi, and is currently an Associate Professor at the department of Neuroanaesthesiology and Critical Care. She has published more than 75 research papers in national and international journals, and contributed numerous book chapters. She also received the prestigious Dr. TN. JHA Memorial award from the Indian Society of Anaesthesiologists and the Smt. Chandra and Sh. Narayan Wadhwani memorial award. She has edited three books related to neuroanesthesia, neurotrauma and geriatric neuroanesthesia. She is also a reviewer for national as well as international journals.

Blurb

This book discusses the underlying mechanisms connecting the brain and heart. The physiology of the brain is such that it is easily affected by any altered physiology of other systems, which in turn may compromise cerebral blood flow and oxygenation. Together, the brain and heart control our body systems, allowing them to function automatically. This interaction between the brain and other systems makes it important for us to understand how any kind of injury to the brain can produce complications in remote organs or systems, such as the heart. The central nervous system is responsible for vegetative function and is central to homeostasis. Further, central nervous system responses are linked to the ongoing function of other organ systems e.g. feeding, thermoregulation, reproduction and muscle activity. It is therefore logical that neural control of the cardiovascular system must also interact with the neural control of other organ systems. This book explains in detail stressed cardiac conditions, discussing the pathophysiology and proposed treatment, and also describing lesser-known crosstalks between the acutely or chronically affected brain and heart.