Brain Tumor Immunotherapy

ISBN-13: 9781617371103 / Angielski / Miękka / 2010 / 374 str.

Linda M. Liau; Donald P. Becker; Timothy F. Cloughesy

Opis

An authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying brain tumor immunotherapy. Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.

Recenzje

"...this multiauthored book is sufficiently complete to support the notion that malignant brain tumors in situ are amenable to therapies designed to isolate, amplify, and focus aspects of the immune response with respect to these tumors...Part II, Introduction to Immunotherapy of Brain Tumors, contains two very good chapters that provide the rational bases for numerous immunotherapeutic approaches covered in the remaining 12 chapters. ...Part III, Adoptive Cellular Immunotherapy, covers the more important issue of cell-mediated immunotherapy from both active immunization and adoptive transfer of ex vivo-expanded effector lymphocytes....Part IV Antiboby-Mediated Immunotherapy, contains four concise reviews of some of the more interesting anti-body-based approaches in treating brain tumors....This text should be a very useful reference for investigators who are interested in any therapeutic modality that involves (or affects) the immune system of patients with intrinsic brain tumors."- Neuro-Oncology

"Brain Tumor Immunotherapy is a unique text in its compilation of current knowledge and experimental events from an authoritative panel of researchers and clinicians who describe the ongoing trends in immunotherapy research as promising therapeutic tools for the treatment of brain tumors....The basic concepts necessary to understanding immunotherapeutic approaches to the treatment of brain tumors are superbly presented in Part II....A concise but excellent overview of the immune system as applied to the central nervous system, this chapter presents the issues that later chapters deal with, namely heterogeneity of tumors, "restricted" immunological privilege, antigen-presenting mechanisms, and cellular immunogenic responses of the central nervous system, as well as the potential risk of allergic encephalomyelitis induction." - Journal of Neurosurgery

Spis treści

Part I. Introduction to the Disease. Neuropathology and Molecular Pathogenesis of Primary Brain Tumors, Paul S. Mischel and Harry V. Vinters. Epidemiology of Primary Brain Tumors, Susan Preston-Martin, Faith Davis, and Roberta McKean-Cowdin. Current Therapy for Primary Brain Tumors, John M. Duff, Pierre-Yves Dietrich, and Nicolas de Tribolet. Part II. Introduction to Immunotherapy of Brain Tumors. Immunostimulation and Immunomodulation of Brain Tumors, Victor C. K. Tse and Frances K. Conley. Biological Principles of Brain Tumor Immunotherapy, Amy B. Heimberger, Darell D. Bigner, and John H. Sampson. Part III. Adoptive Cellular Immunotherapy of Brain Tumors. Systemic T-Cell Immunotherapy for Brain Tumors, Gregory E. Plautz and Suyu Shu. Cytotoxic T-Lymphocytes Reactive to Patient Major Histocompatibility Complex Proteins for Therapy of Brain Tumors, Carol A. Kruse and David Rubinstein. Autologous Vaccine and Adoptive Cellular Immunotherapy as Treatment for Brain Tumors, Gary W. Wood and Frank P. Holladay. Part IV. Antibody-Mediated Immunotherapy of Brain Tumors. Anti-Idiotype Immunotherapy Strategies for Brain Tumors, Nai-Kong V. Cheung. Radiolabeled Antibodies for Therapy of Brain Tumors, Carol J. Wikstrand, Michael R. Zalutsky, and Darell D. Bigner. Immunotoxin Therapy of Brain Tumors, Walter A. Hall. Antibodies to Adhesion Molecules for Immunotherapy of Brain Tumors, S. Ather Enam. Part V. Tumor Vaccines and Other Strategies. Cytokine-Based Immuno-Gene Therapy for Brain Tumors, Roberta P. Glick, Terry Lichtor, and Edward P. Cohen. Downregulation of Transforming Growth Factor b as Therapeutic Approach for Brain Tumors, Habib Fakhrai, Svetlana Gramatikova, and Rohangiz Safaei. Dendritic Cell Immunotherapy for Brain Tumors, Stéphane Vandenabeele, Linda M. Liau, and David Ashley. Death Ligand/Death Receptor-Mediated Apoptosis for Treatment of Brain Tumors, Wilfried Roth and Michael Weller. Combining Radiation Therapy with Immunotherapy for Treatment of Brain Tumors,William H. McBride. Index.

Blurb

It is now clear from basic research and clinical trials that immunotherapy for brain tumors is feasible, can evoke relevant biologic responses, and can yield important insights into human biology. In Brain Tumor Immunotherapy, an authoritative panel of researchers and clinicians critically reviews the entire field to provide a comprehensive guide to modern brain tumor immunotherapy and thereby enhance future research in this area. The contributors detail many of the key laboratory experiments and clinical protocols that are currently being investigated, integrate the available information from previous and ongoing research, and help define the current status of the field. Topics range from adoptive cellular and antibody-mediated immunotherapy of brain tumors to tumor vaccines and related strategies, and include many vanguard experimental strategies and immunological techniques for studying tumor immunotherapy. Introductory material brings the reader up-to-date on the biological principles of brain tumor immunotherapy, along with the neuropathology, molecular pathogenesis, epidemiology, and the relevant current therapies.
Cutting-edge and comprehensive, Brain Tumor Immunotherapy brings together all the important recent advances in our understanding of central nervous system tumor immunology and illustrates in powerful detail the many new applications now harnessing the immune response for brain tumor therapeutics.