Brain Slices in Basic and Clinical Research

ISBN-13: 9780849347603 / Angielski / Twarda / 1995 / 352 str.

Benjamin M. Rigor; Avital Schurr

Opis

Brain Slices in Basic and Clinical Research describes advancements in the field of brain function and dysfunction through use of central nervous system slice preparations. Topics are authored by leading scientists and include the following:

Mechanisms of synaptic plasticity as the basis of memory processes

Chaos and synaptic variability

Brain calcium currents

Glutamate receptors

Pathophysiology of excitotoxins

Cerebral hypoxia-ischemia

Neuronal injury

Free radicals

Optical methods of measuring brain metabolism

Voltammetry in brain slices

Calcium imaging

Patch-clamp recording and application of macromolecules through patch-clamp pipettes in brain slices

Intracellular double labeling of various neuronal populations

Use of brain slices in teaching neurophysiological methods
Most of the topics are published in book format for the first time, and some of the techniques are more fully detailed than in any other book.

Recenzje

"...a valuable resource for graduate students, postdoctoral fellows, and even principal investigators interested in learning how to apply brain slice technology to the study of neurological function."
-Trends in Endocrinology and Metabolism

Spis treści

Advances in Understanding the Mechanisms Underlying Synaptic Plasticity, T. Teyler, I. Cavus, C. Coussens, P. DiScenna, L. Grover, Y. Lee, and Z. Little
Chaotic Components of Synaptic Variability in Hippocampal Pathways, P.G. Aitken, S.J. Schiff, and T. Sauer
Intrinsic Optical Properties of Brain Slices: Useful Indices of Electrophysiology and Metabolism, T.J. Sick and J.C. LaManna
Voltammetry in Brain Slices, J.A. Stamford
Imaging of Intracellular Calcium in Hippocampal Slices: Methods, Limitations, and Achievements, M. Segal and J.M. Auerbach
Patch-Clamp Recording in Brain Slices, F.A. Edwards
Intracellular Application of Macromolecules through Patch Pipettes in Brain Slices, M. Alreja and G.K. Aghajanian
Intracellular Double Labeling of Substantia Nigra and Pedunculopontine Neurons in In Vitro Slice Preparation, S.T. Kitai and Y. Kuga
The Importance of Temperature Control When Investigating High-Threshold Calcium Currents in Mammalian Neurones, R.H. McAllister-Williams and J.S. Kelly
A Neurochemical Approach to Elucidate Metabotropic vs. Ionotropic Glutamate Receptor Activities in Rat Hippocampal Slices, D.D. Schoepp and M.A. Desai
Radiotracer Labeling of Brain Slices, G.C. Newman, F.E. Hospod, C.S. Patlak, and H. Qi
The Pharmacology of Excitotoxins and Energy Deprivation in Hippocampal Slices, A. Schurr and B.M. Rigor
Delayed Neuronal Injury in the Hippocampal Slice, R.-A. Wallis and K.L. Panizzon
Gene Expression as an Index of Pathophysiology Associated with Slice Preparation, T.S. Nowak, Jr., Q. Zhou, P.J. Voulalas, and J.M. Sarvey
Studies on Anoxic Depolarization, M. Balestrino
The Use of Brain Slices in the Study of Free Radical Actions, T.C. Pellmar
Using the In Vitro Hippocampal Slice as a Model to Teach Methods in Neurophysiology, S. Veregge

O autorze

Schurr\, Avital; Rigor\, Benjamin M.