Brain Plasticity: Development and Aging

ISBN-13: 9781475795530 / Angielski / Miękka / 2013 / 332 str.

Guido Filogamo;Antonia Vernadakis;Fulvia Gremo

Opis

This book is dedicated to the memory of two colleagues and friends, Amico Big- nami and Hendrick Vander Los. They were both pioneers in their fields: Bignami on on- togenesis and function of neuroglia, and Van der Los on brain plasticity and neuronal circuitry. Their ideas are further pursued by the authors in this book. Some of the chapters are products of a conference dedicated to these two scientists entitled "Recent Advances in Neurobiology: Plasticity and Regeneration." The conference was organized by the Insti- tute of Developmental Neuroscience and Aging and sponsored by the Region della Valle d' Aosta. Also, several chapters are written by colleagues who knew well either Amico or Hendrick and were invited to contribute to this dedication. The book is divided in four sections. The first part covers neurons, neuroglia includ- ing microglia, their plasticity and phenotypic expression, and specific functions and inter- actions. It is now established that neuroglia are an intimate component of the neuronal environment and thought to regulate several neuronal functions. More recently microglia have become prominent as the immune cells in the CNS. This part contributes new infor- mation for these cellular interactions. The second part deals with neuronal and glial cell plasticity as it relates to regeneration and neurodegeneration, more or less an extension of Part I. In recent years the role of transplantation in regeneration has become promising.

Spis treści

Regulatory Mechanisms of Expression of Neuronal and Glial Phenotypes: Genes Controlling Neural Fate and Differentiation; R. Matsas. Neuronal Plasticity in Development: Lessons from Ethanol Neurotoxicity during Embryogenesis; S. Kentroti. Plasticity in Astrocytic and Cytoskeleton Signaling; D. Mangoura, et al. Neuronal Circuitry, Synaptic Plasticity, Regeneration: Anatomical and Functional Characterization of Transpatent Monoemicinergic Neurons in Paraplegic Rats; M. Gimenez y Ribotta, et al. Regulation of Glial Energy Metabolism; P.J. Magistretti, L. Pellrin. Dendric Development of Visual Callosal Neurons; A. Vercelli, et al.. Neuronal Cell Death, Neuroprotection: Nerve Growth Factor and Oxidative Stress in the Nervous System; Z. Pan, et al. Role of Astrocytes in Glutamate Homeostasis: Implications for Excitoioxity; A. Schousboe, et al. Neurotrophins and Neuromodulators, Neurohormones, Cell Adhesion Molecules: Steroid and Protein Regulators of Glial Cell Proliferation; L. Goya. 13 additional articles. Index.