Brain Metastasis

ISBN-13: 9789400988019 / Angielski / Miękka / 2011 / 470 str.

L. Weiss; H. a. Gilbert; J. B. Posner

Opis

Of those people dying with cancer, many die as a result of metastases. In spite of this, a surprisingly small number of texts have been devoted to this clinically important topic. The present series of monographs originated in discussions, which convinced us of the need for texts on metasasis which would contain not only basic and clinical observations on human beings and where neces sary, on experimental animals but also discussions of the state of the art in diagnosis and therapy. In order to achieve this in-depth approach, for which publication was preceded by small workshops, it was necessary to impose limitations on the scope of the topic. Metastasis is therefore dis cussed by site, and the series is organized accordingly. The first volume in the series, Pulmonary Metastasis, was an expanded version of a Workshop held at Roswell Park Memorial Institute in 1977. This, the second volume, is based on a similar workshop on metastasis to the brain, held at the Memorial Sloan-Kettering Cancer Center in September, 1978. In organiz ing both the workshop and in editing this volume, we have been excep tionally fortunate to receive the generous cooperation of Dr. Jerome B. Posner, a practicing neurologic oncologist who has given freely of his ex pertise in this specialized field."

Spis treści

1 Basic Aspects of Brain Metastasis.- 1 Brain Metastases: A Clinician’s View.- 2 The Cell Periphery and Metastasis.- 3 Experimental Brain Metastasis.- 4 The Role of Brain Metastases in Cascade Processes: Implications for Research and Clinical Management.- 5 Arrest and Extravasation of Cancer Cells with Special Reference to Brain Metastases and the Microinjury Hypothesis.- 6 Quantitative Aspects of Osmotic Opening of the Blood-Brain Barrier.- 7 Brain Tumor Microvasculature.- 8 A Model for Brain Metastasis.- 9 Pharmacokinetics and Metastatic Brain Tumor Chemotherapy.- 10 Human Cancer Immunology.- 2 The Diagnosis of Brain Metastases.- 11 Clinical Manifestations of Brain Metastasis.- 12 Computed Tomography of Metastatic Disease of the Brain.- 13 Radionuclide Imaging of Cancer Metastases in the Brain.- 14 Positron-Emission Tomography.- 3 The Treatment of Brain Metastasis.- 15 Analysis of the Benefit of Palliation of Brain Metastases.- 16 The Memorial Hospital Experience.- 17 The Hahnemann Experience.- 18 RTOG Experience and New Concepts.- 19 The Princess Margaret and Ontario Cancer Foundation Experience.- 20 The Southern California Permanente Medical Group Experience: Functional Results.- 21 Clinical Effects of Radiation on the Adult Nervous System.- 22 Chemotherapy of Metastatic Central Nervous System Carcinoma.- 23 Adrenocorticosteroid Hormones.- 24 Combined Chemotherapy and Irradiation in the Treatment of Brain Metastases from Lung Cancer.- 25 Surgical Therapy of Brain Metastases.- 26 Treatment of Brain Metastases by Surgical Extirpation.- Appendix Neuropathology Work Book.