Brain Drug Targeting : The Future of Brain Drug Development

ISBN-13: 9780521800778 / Angielski / Twarda / 2001 / 372 str.

William M. Pardridge

Opis

In this innovative and challenging book, William Pardridge, a world leader in the study of the blood-brain barrier and its clinical implications, argues that brain drug development has been restricted by the failure of adequate brain drug targeting. This is an increasingly urgent problem as developments in genomics lead to new generations of therapeutic macromolecules. The author reviews the field of neurotherapeutics from the point of view of drug targeting. He surveys the scientific and clinical basis of drug delivery across biological membranes, including topics such as genetically engineered trojan horses for drug targeting, antisense neurotherapeutics, and gene therapy of brain disorders. At a time when there are few significant new drug treatments in prospect for common neurological diseases, this authoritative review will encourage a wide range of clinicians and neuroscientists to reexamine the development and use of drugs in treating disorders of the central nervous system.

Recenzje

Review of the hardback: 'This is an excellent book to be expected from a major researcher in the field. The lucid text is illuminated by an eclectic mix of diagrams and plates that will have a broad appeal to a wide audience.' A. Davenport, British Journal of Neurosurgery

Spis treści

Preface; 1. Drug targeting, drug discovery, and brain drug development; 2. Invasive drug delivery; 3. Lipid-mediated transport and carrier-mediated transport of small molecules; 4. Receptor-mediated transcytosis of peptides; 5. Vector discovery: genetically-engineered trojan horses for drug targeting; 6. Linker strategies: the engineering of multi-functional drug formulations; 7. Protein neuropathies and peptide radiopharmaceuticals; 8. Antisense neurotherapeutics and imaging gene expression in vivo; 9. Gene therapy of the brain; 10. Blood-brain barrier genomics; Epilogue; Bibliography.