Brain Damage and Repair: From Molecular Research to Clinical Therapy

ISBN-13: 9781402018923 / Angielski / Twarda / 2004 / 721 str.

T. Herdegen; J. Delgado-Garcia

Opis

This book builds a novel bridge from molecular research to clinical therapy. This approach reveals the functional features of neurons and glia in the particular context of vulnerability and self-protection, intracellular properties and extracellular matrix. Arising from this platform, this volume unfolds the molecular and systemic processes underlying migration disorders, axonal injury, repair and regeneration.

Spis treści

Accompanying Words. Preface. Members of the Management Committee.

A: The Vulnerable Neuron or Why Neurons Die. 1. The aging brain - the burden of life; S. Hoyer, K. Plaschke. 2. Gene expression and its regulation in neurons; L. Kaczmarek. 3. Morphological peculiarities of the neuron; I.P. Johnson. 4. Synaptic plasticity: hyperexcitability and synaptic silencing; L. Martínez-Millán, G. García del Caño, I. Gerrikagoitia. 5. The axonal burden; H. Aldskogius. 6. The self-destruction of neurons - physiological and pathophysiological decisions for the functional integrity; J. Prehn, D. Kögel. 7. The organelles I: Mitochondrial failure; J.M. Cuezva. 8. The organelles II: Endoplasmic reticulum and its overload; W. Paschen. 9. Transcriptional dysfunctions as pathogenic mechanism of neurodegenerative diseases; B. Kaminski. 10. Formation of radicals; M. Götz, M. Gerlach.

B: The Extraneuronal Matrix - Sites of Multiple Degenerative Processes. 11. Axon guidance and repulsion. The molecular code of social life in the brain; J.A. del Río, F. de Castro, E. Soriano. 12. Microglia and the cerebral defence system; D. van Rossum, U.K. Hanisch. 13. Generation and differentiation of astrocytes during central nervous system development and injury; C. Vicario-Abejón, M.J. Yusta-Boyo. 14. Oligodendrocytes in health and disease; C. Domercq, C. Matute. 15. The myelin glial cell of the peripheral nervous system: The Schwann cell; D. Echevarría, S. Martinez. 16. The Müller glia: role in neuroprotection; E. Vecino, M. García.

C: The Brave Neuron - Self-Protection, Plasticity and Restoration. 17. Neural plasticity and regeneration: myths and expectations; J.M. Delgado-García, A. Gruart. 18. Neuronal protection against oxidative damage; O.S. Jørgensen, A.S. Nielsen. 19. Functional recovery in the peripheral and central nervous system after injury; D. González-Forero, B. Benítez-Temiño, R.R. de la Cruz, A.M. Pastor. 20. Neural plasticity and the cell biology of learning; M. Nieto-Sampedro. 21. Neural plasticity and central nervous system lesion repair; M. Nieto-Sampedro. 22. Regulation of the intrinsic growth properties in mammalian neurons; F. Rossi. 23. Glutamate, calcium and neurodegenerative disease: impact of cytosolic calcium buffers and their potential role for neuroprotective strategies; F. Bergmann, B.U. Keller. 24. Postnatal neurogenesis and neuronal regeneration; C. López-García, J. Nacher. 25. Migration disorders and epilepsy; C. Haas, M. Frotscher.

D: Therapeutic Principles. 26. Invasive strategies as therapeutic approaches for central nervous system diseases; J.A. Armengol. 27. General aspects of neuropharmacology in relation to brain repair following trauma; A. Ribeiro. 28. Stem cells and nervous tissue engineering; I. Liste, A. Martínez-Serrano. 29. Cell transplants and artificial guides for nerve repair; X. Navarro, V. Verdú. 30. Modern late neurologic rehabilitation: neuroscience and motivating functional rehabilitation; P. Bach-y-Rita. 31. Viral gene delivery; S. Isenmann.

E: The Neurodegenerative Disorders: Molecular Pathogenesis and Treatment. 32. General remarks on the bridging between basic research and clinics; P. Kermer, M. Bähr. 33. Mechanical lesions of the peripheral nervous system; C. Krarup. 34. Stroke and ischemic insults; V. Ceña, M. Fernández, C. González-García, J. Jordán. 35. Parkinson's disease I: Degeneration and dysfunction of dopaminergic neurons; H. Wilms, G. Deuschl. 36.Parkinson's disease II: Replacement of dopamine and restoration of striatal function; C. Winkler, Kirik. 37. Alzheimer's disease; R. Alberca, E. Montes. 38. Amyotrophic lateral sclerosis and related disorders; R. Dengler, J. Buffler. 39. Pharmacological strategies for neurodegeneration and overview of clinical trials; L. Ley, T. Herdegen. 40. Monitoring brain dysfunction through imaging techniques; M. Ptito, R. Kupers. 41. Functional assessment of human brain with non-invasive electrophysiological methods; J.L. Cantero, M. Atienza. 42. Legal implications of therapeutic options; M. Herdegen.

F: Glossary.

G: List of Contributors.

H: Index.