Brain Aging and Therapeutic Interventions

ISBN-13: 9789400793712 / Angielski / Miękka / 2015 / 296 str.

Mahendra K. Thakur; Suresh I. S. Rattan

Opis

This book brings together most up-to-date information on different aspects of brain aging and on the strategies for intervention and therapy of age-related brain disorders. It includes 18 chapters by leading researchers, and each chapter is a comprehensive and critical review of the topic in question, discusses the current scenario and focuses on future perspectives. The target readership is the undergraduate and graduate students in the universities, in medical and nursing colleges, along with the post-graduate researchers and practicing clinicians who would like to know about the latest developments in the field of neurodegenerative disorders and their therapeutic interventions. This book will be of much interest to pharmaceutical, nutrition and healthcare industry for an easy access to accurate and reliable information in the field of aging research and intervention.

Recenzje

From the reviews:

"This textbook concerns the effects of hormonal deficiencies and imbalances in relation to the HPA and the effects upon the aging brain. ... I recommend this book to obstetricians, gynecologists, neurologists, and neuroscientists who already have an interest in women's health." (Joseph J. Grenier, Amazon.com, March, 2014)

Spis treści

Editorial.- Contributors.- 1 Brain aging: a critical reappraisal, Mahendra K Thakur, Arpita Konar, Akash Gautam .- 2 Base excision DNA repair: the house keeping guardian for genomic stability in the brain, Umakanta Swain, Kalluri Subba Rao.- 3 Role of brain-derived neurotrophic factor as a modulator of synaptic plasticity, Yasuyuki Ishikawa, Masami Kojima. 4 Mitochondrial dysfunction in sporadic Alzheimer's disease: mechanisms, consequences and interventions, Sasanka Chakrabarti, Maitrayee Sinha.- 5 Brain Aging: Influence of early–life events on late-life brain disorders, Debomoy K Lahiri.- 6 The importance of the environment in brain aging: Be happy, live longer, Mónica De la Fuente, Lorena Arranz.- 7 Consequences of altered mortalin expression in control of cell proliferation and brain function, Renu Wadhwa, Sunil C Kaul.- 8 Age induced alterations in biological clock : Therapeutic effects of melatonin changes in regulation of biological clock, Anita Jagota.- 9 Neurolipofuscin in aging and aluminum-induced aging: Possible therapeutic interventions, Mahdi Hasan, Sandeep Tripathi, Abbas A Mahdi.- 10 Dietary restriction as a potential intervention to retard age-associated impairment of brain functions, Gurcharan Kaur, Sukhwinder S Lakhman.- 11 Understanding mechanism of action of herbal drugs in age-related degenerative brain disorders, Maheep Bhatnagar, Ayushi Jain, Neha Jaiswal, Chavi Sharma, Pooja Suvalka.- 12 Neurodegeneration in hypoxia: implications in aging, Kalpana Barhwal Hota, Sunil Kumar Hota, Shashi Bala Singh.- 13 Stress and memory; from mechanisms to long-lasting consequences, Harmen J Krugers, Marian Joels.- 14 Estrogen mediated neuroprotection: Hope to combat neuronal degeneration and synaptic plasticity post-menopause, Raj D Mehra,  Mukesh K Varshney, Pavan Kumar.- 15 Potential therapeutic targets for memory impairments and dementia: Clues obtained from memory-enhanced mice, Shogo Endo.- 16 Potential beneficial effects of a diet with walnuts in aging and Alzheimer’s disease , Abha Chauhan, Ved Chauhan.- 17 Smart dietary interventions and prevention of cognitive decline with aging, S Asha Devi.- 18 Herbal cognitive enhancers: New developments and challenges for therapeutic applications, Andrea Zangara, Keith A Wesnes.- Index

Blurb

The proposed book will be a multi-author review book comprised of relevant chapters written in the form of critical reviews by the leading researchers in their respective fields. The format of the articles will be in semi-academic style in which research data from various experimental systems will be presented while focusing on their applications in human beings with respect to the prevention and treatment of age-related impairments in brain functions. The book will consist of about 18 chapters, each of which will be on an average 16 pages long giving about 300 pages. Each chapter will be a comprehensive and critical review of the topic in question presenting important data in a tabulated form, and wherever necessary using photographs and line drawings. It will provide an authoritative and up-to-date account of a specific topic with a comprehensive list of citations of original research papers and review articles.