Bone Metastasis

ISBN-13: 9781617375453 / Angielski / Miękka / 2010 / 344 str.

Gurmit Singh; Shafaat A. Rabbani

Opis

A state-of-the-art review of the molecular underpinnings of bone-seeking cancers, current treatment approaches for them, and future therapeutic strategies. The authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. They also discuss the various strategies that appear to have promise and are currently deployed in treatment or are at the experimental stage.

Spis treści

Part I. Fundamental Concepts Overview Sadmeet Singh and Gurmit Singh Parathyroid Hormone-Related Peptide and Malignancy David Goltzman Vitamin D and Vitamin D Analogs in Cancer Progression and Metastasis Richard Kremer and Shafaat A. Rabbani Role of TGF-b and IGF in Tumor Progression and Bone Metastases Erin Giles and Gurmit Singh Biologic and Therapeutic Implications of Osteomimicry and Epithelial-Mesenchymal Transition in Prostate Cancer Wen-Chin Huang, Valerie Odero-Marah, and Leland W. K. Chung Roles of Immune-Cell-Derived Matrix Metalloproteinases in Tumor Growth and Metastasis Kristina A. Szabo and Gurmit Singh Contribution of Osteopontin to the Development of Bone Metastasis Alison L. Allan, Alan B. Tuck, Vivien H. C. Bramwell, Theodore A. Vandenberg, Eric W. Winquist, and Ann F. Chambers Role of Interleukin-11 in Osteolytic Bone Metastasis Ryan R. Simon, Martin K. Butcher, and Stephen G. Shaughnessy Cell Adhesion Molecules in Tumor Metastasis Sujata Persad and Gurmit Singh PTHrP and Cancer: Prostate and Lung Leonard J. Deftos, D. W. Burton, and Randolph H. Hastings Antithrombotics in Tumor Growth and Metastasis Shaker A. Mousa Part II. Therapeutic Strategies Challenges and Strategies in the Analysis of Multiple Events in Oncology Pierre P. Major and Richard J. Cook Integrins: Novel Targets for the Treatment of Bone Metastasis Graham C. Parry, Fernando Doñate, Marian L. Plunkett, David E. Shaw, Steven Pirie-Shepherd, and Andrew P. Mazar Bone Metastasis and Pathological Fractures: Bone Tissue Engineering as a Novel Therapy Laurie A. McDuffee, Nigel Colterjohn, and Gurmit Singh Role of Photodynamic Therapy for Bone Metastasis Shane Burch and Albert J. M. Yee Docetaxel for Metastatic Cancer and Its Rolein Combination Therapies for Advanced Prostate Cancer Ellen K. Wasan, Martin Gleave, Karen Fang, Kim Chi, Gwyn Bebb, Lincoln Edwards, and Marcel B. Bally Use of Tetracyclines for Bone Metastases Eric Seidlitz, Zeina Saikali, and Gurmit Singh Role of Bisphosphonates in Skeletal Metastases Arif Hussain and Fred Saad Radiation Treatment of Bone Metastases Edward Chow, Jackson Wu, and Elizabeth Toni Barnes Index

Blurb

Bone metastasis occurs in 60 to 85% of all breast, prostate, and lung cancer patients and is responsible for increasing morbidity. In Bone Metastasis: Experimental and Clinical Therapeutics, leading bone metastasis experts from around the world explain the molecular underpinnings of the process, review current treatment approaches, and outline future therapeutic strategies. On the basic science side, the authors illuminate the role of various autocrine, paracrine, and immunological factors involved in the progression and establishment of bone metastases, highlighting the physiological processes that lead to bone degradation, pain, angiogenesis, and dysregulation of bone turnover. On the therapeutic side, the authors discuss various strategies that appear to have promise and are currently deployed in treatment or at the experimental stage. They show how the treatment of bone metastases may need to be individualized through a combination of surgical, radiation, and/or pharmacological maneuvers. Their analysis of various pharmacogenomic parameters and tissue environmental factors sets the stage for progress beyond the current standards of using radiation and/or bisphosphonates for palliation.
State-of-the-art and innovative, Bone Metastasis: Experimental and Clinical Therapeutics elucidates for all those involved-whether in research or clinical treatment of bone-seeking cancers-the biological processes and therapeutic advances that are already generating significant improvement in the cancer clinic.