Bloodtransfusion and Problems of Bleeding

ISBN-13: 9789400976948 / Angielski / Miękka / 2011 / 308 str.

C. Th Smit Sibinga; P. C. Das; J. J. Van Loghem

Opis

J.J. Van Loghem Previously to this symposium, five others have taken place in Groningen. The first one in 1976. This yearly scientific happening has continued. It has greatly stimulated the in- terest in blood transfusion and all allied disciplines in our country. It is clear that these meetings are organized not only by a good scientist, but at the same time by a gifted or- ganizer who, as director of the Red Cross Blood Bank Gro- ningen-Drenthe, has shown that the heavy load of daily routine work can very well be combined with a large amount of experimental and clinical research in blood component therapy, coagulation disorders, blood group genetics and serology, the latter in cooperation with the Blood Group laboratory of the University Hospital Groningen under the directorship of Dr. Van Dijk. All these activities show how much a well-organized blood bank can contribute to a national blood transfusion orga- nization.

Spis treści

I. Blood Coagulation and Blood Components.- The biochemistry of blood coagulation.- Blood coagulation: Laboratory practice.- The magic of fresh whole blood.- Blood components: Why and what for?.- Discussion.- II. Platelet Function and Platelet Therapy.- Platelet function tests.- Beta-thromboglobulin: A story of value?.- Platelet therapy.- Cryopreservation of platelet concentrate: A comparison of DMSO and glycerol systems.- Discussion.- III. Shock and Massive Blood Loss.- Pathophysiology of hemorrhagic shock: Clinical and therapeutic implications.- Plasma fibronectin: Biochemical properties and clinical relevance.- Disseminated intravascular coagulation and its impact on blood transfusion.- Colloid or crystalloid in the resuscitation of hemorrhagic shock: A controlled clinical trial.- Liver transplants: Facing the facts of massive blood loss.- Transfusional prevention of the massive transfusion syndrome.- Discussion.- IV. Hemophilia Home Care: Practical Experience.- Home care: The need for control.- New England hemophilia center: A comprehensive home care model.- Discussion.- V. Hemophilia Home Care: Social and Legal Aspects.- Social aspects of hemophilia.- Hemophilia and the borders of life.- Hemophilia in professional life.- The legal aspects of hemophilia. What is possible in the Netherlands and what are the conditions?.- Discussion.- VI. Hemophilia Home Care for the Future.- A. Factor VIII.- Factor VIII supply: The sword of Damocles in a national self-sufficient plasma procurement program.- National resources and the use of Factor VIII.- New developments in F VIII purification, an overview.- Purified Factor VIII: A high yield production method for routine blood banks.- The effects of heparin on Factor VIII recoveries: Markedly improved yields.- Use of DDAVP in blood donors.- Discussion.- B. Hepatitis.- Hepatitis B virus vaccine.- ?-Propiolactone/ultraviolet treatment: Quantitative studies on effectiveness for inactivation of hepatitis B in human plasma.- Report of a Dutch HB-vaccine.- Discussion.