Blood Substitutes and Oxygen Biotherapeutics

ISBN-13: 9783030959746 / Angielski / Twarda / 2022

Opis

This book functions as a comprehensive and authoritative reference book in blood transfusion and blood substitutes. It is a collection of the latest developments and the newest investigations, and individual chapters are written by world experts in the arena.

The book begins with a historical review on the practice of transfusions as well as the components and physiology of blood. The following chapters cover various topics, including platelet substitutes, hemoglobin-based oxygen carriers, perfluorocarbon based oxygen carriers, and safety issues related to artificial hemoglobin. All chapters provide a bulleted highlights list to facilitate readers in mastering the main points of each individual chapter.  Blood Substitutes and Oxygen Biotherapeutics is an invaluable reference book for perioperative care providers, hematologists, anesthesiologists, surgeons, obstetricians and gynecologists.

Spis treści

Chapter

Section I Transfusion: Science and Practice

1

ERYTHROCYTE TRANSFUSION: BRIEF HISTORY AND CURRENT PRACTICE

2

ATP and Oxygen: the Energy Economy of the Cell

3

Physiological Functions of Blood 

4

Hemoglobin: Physiology and Hemoglobinopathy

5

The Global Burden of Anemia 

6

Blood Component Therapy: the History, Efficacy, and Adverse Effects in Clinical Practice

7

Allogeneic Blood Transfusion: Complications and Side Effects

8

THE  REAL-TIME  EFFECTS  OF  ARTIFICIAL  BLOOD  SUBSTITUTES  ON  THE MICROCIRCULATION

9

Vascular endothelium and nitric oxide

10

A Brief History of Development of Nanobiotechnology-based Blood Substitutes

Section II Pharmacology and Physiology of Oxygen Therapeutics

11

Classification of Blood Substitutes  

12

Hemoglobin-based Oxygen Carriers: Brief History, Pharmacology and Design Strategies, Review of the Major Products in Failed Clinical Trials, On-Going Studies, and Coagulation Concerns.

13

Complications of HBOCs including clinical safety issues

14

Free Hemoglobin Toxicity

15

Nanotechnology-based oxygen and drug carriers

16

Perfluorocarbon-based Oxygen Carriers  LSU team will work on it

17

Platelet Substitutes      

18

Plasma Substitutes: Synthetic Colloid and Renal Toxicity

Section III  Products in Development

19

Novel nanobiotherapeutic based blood substitutes

20

Paradigm Shift for Designing Oxygen Therapeutics: New Insights Emerging from Studies with Transgenic Mouse Models of Sickle Cell Disease

21

Hemoglobin-Based Blood Substitute With Pharmacological Activities of ATP, Adenosine and Glutathione: A Review of Preclinical and Early Clinical Experience

22

Hemoglobin vesicles as artificial red cells   

23

Low Volume Resuscitation Agents in Prehospital Medicine needs bullets needs modification

24

ErythroMer: Bio-Inspired Artificial Red Blood Cell

25

OxyVita:  History, Studies, and Future

26

Erythrocruorin as a novel blood substitute

Section IV Products, not Approved,  in Progress, and Approved for Human/Veterinary Use

27

HemAssist: History, clinical trials and lessons learned   

28

Development of Recombinant Hemoglobin-Based Oxygen Carriers-Somatogen: Studies and Lessons Learned

29

Hemolink: History, Clinical Trials and Lessons Learned

30

PolyHeme: History, Clinical Trials, and Lessons Learned

31

Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study (OLD CH3)
in Stable Adult Patients with Sickle Cell disease

32

Oxygent: A Perfluorochemical-based Oxygen Therapeutic for Surgical Patients

33

Sanguinate: History and clinical evaluation of a multi-modal HBOCs  Bryan Romito

34

M101, the Hemoglobin from the Sea: History and Therapeutic Perspectives 

35

Hemopure:  clinical trials and current status

36

Perftoran: History, Studies, Approval and Use in Russia, and Moving Forward  Henry will review it offering a college student to review it?

37

Oxycyte

38

Hemoximer

Section V Specific Indications, Regulatory Issues and Future Directions

39

Transplantation and Hemoglobin-based O2 Carriers  by end of April

40

Hemorrhagic Shock: Role for Oxygen Therapeutics in Military and Civilian Trauma, early June

41

HBOCs in Trauma

42

Use of Oxygen Therapeutics in Patients for Whom Blood is Not an Option, and Moving Forward wait for several weeks to Mid-late April

43

Regulatory Update: How to Get an Oxygen Therapeutic Approved for Clinical Use 

O autorze

Henry Liu M.D

Pennsylvania State University College of Medicine

Milton S. Hershey Medical Center

Anesthesiology & Perioperative Medicine

Hershey, Pennsylvania 17033

USA

 

Dr. Alan David Kaye, MD, PhD, DABA, DABPM, DABIPP, FASA

Vice-Chancellor of Academic Affairs, Chief Academic Officer, and Provost, 

Tenured Professor of Anesthesiology and Pharmacology, Toxicology, and Neurosciences, 

Pain Fellowship Program Director, 

LSU School of Medicine, 1501 Kings Hwy, Shreveport, LA 71103

 

Jonathan S. Jahr

David Geffen school of Medicine at UCLA

Los Angeles

California