Blanco's Overview of Alpha-1 Antitrypsin Deficiency: History, Biology, Pathophysiology, Related Diseases, Diagnosis and Treatment

ISBN-13: 9780128095300 / Angielski / Twarda / 2017 / 252 str.

Ignacio Blanco

Opis

Blanco's Overview of Alpha-1 Antitrypsin Deficiency: History, Biology, Pathophysiology, Related Diseases, Diagnosis, and Treatment is a robust introduction to topics associated with Alpha-1 Antitrypsin Deficiency (AATD). Included are topics ranging from the history of the disease, biology, pathophysiology, related diseases, including the two major manifestations of the disease (liver disease and lung disease), and diagnosis and treatment. The book addresses the need for the amalgamation of current and novel concepts and practices in the field of AATD. AATD is under-recognized in the medical community and, as a result, it is underdiagnosed. The book provides increased awareness and understanding of the condition to improve diagnosis rates and enhance patient care. This book is an essential tool and reference, beneficial to clinicians who screen and treat AATD patients, as well as research scientists working in the AATD field at junior and senior levels.

• Presents the fundamental theoretical and practical aspects of Alpha-1 Antitrypsin Deficiency (AATD) based on scientific evidence
• Provides evidence to show that AATD is a rarely diagnosed condition, rather than a rare condition
• Contains current research and future perspectives from Dr. Ignacio Blanco, a worldwide expert in the field of alpha-1 antitrypsin and lung and liver disease associated with the deficiency of this antiprotease
• Provides resources to current registries and patient associations

Spis treści

1. Alpha-1 Antitrypsin Deficiency: Introduction and History2. Serpins and Serpinopathies3. Alpha-1 Antitrypsin Biology4. Alpha-1 Antitrypsin Gene, Genetic Heritage, Phenotypes, and Genotypes5. Alpha-1 Antitrypsin Deficiency: Liver Pathophysiology6. Alpha-1 Antitrypsin Deficiency: Lung Pathophysiology7. Genetic Epidemiology8. Laboratory Diagnosis9. Clinical Diagnosis10. Liver Disease Associated With Alpha-1 Antitrypsin Deficiency11. Respiratory Manifestations of the Alpha-1 Antitrypsin Deficiency12. Other Diseases Associated With Alpha-1 Antitrypsin Deficiency13. Clinical Management and Treatment of Lung Disease14. Registries and Patients' Associations15. Current Research and Future Perspectives

O autorze

Ignacio Blanco is the coordinator of the Spanish Registry of Patients with Alpha-1 antitrypsin Deficiency (REDAAT); evaluator of research projects for the Spanish National Agency for Assessment and Forecasting (ANEP).

He is a retired physician and researcher and has held professorships in both the University of Oviedo and the University of Murcia.

Dr. Blanco was an influencial collaborator in the development of the Proyecto IDDEA for the identification and diagnosis of Alpha-1 Antitrypsin Defieciency (AATD) as well as the national screening program for AATD in COPD patients, based on the determination of the Alpha-1 Antitrypsin (AAT) genotype in the Central Laboratoy of the Spanish AAT Registry (Hospital Vall d'Hebron, Barcelona).

He is a founder and member of the Asturian Respiratory Society (ASTURPAR). He is also a member of the European Respiratory Society (ERS) and member of the Spanish Society of Pneumology and Thoracic Surgery (SEPAR). He hold two patents of invention.