Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2

ISBN-13: 9781493955169 / Angielski / Miękka / 2016 / 256 str.

Susanne Zeilinger; Juan-Francisco Martin; Carlos Garcia-Estrada

Opis

​Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

Spis treści

Preface

 

Contributors

 

Chapter 1.    Fungal Secondary Metabolites in the “OMICS” Era

                     Susanne Zeilinger, Carlos García-Estrada, and Juan-Francisco Martín

 

Chapter 2.    Key Players in the Regulation of Fungal Secondary Metabolism

                     Benjamin P. Knox and Nancy P. Keller

 

Chapter 3.    Epigenetics of Fungal Secondary Metabolism Related Genes

                     Ming-Yueh Wu and Jae-Hyuk Yu

 

Chapter 4.    Genome Mining for Fungal Secondary Metabolic Gene Clusters

                     Grayson T. Wawrzyn, Mark A. Held, Sarah E. Bloch, and Claudia Schmidt-Dannert

 

Chapter 5.    Metagenomics and Metatranscriptomics for the Exploration of Natural Products from Soil Fungi

                     Irshad Ul Haq and Jan Dirk van Elsas

 

Chapter 6.    Metabolomics and Secondary Metabolite Profiling of Filamentous Fungi

                     Bernhard Kluger, Sylvia Lehner, and Rainer Schuhmacher

 

Chapter 7.    Fungal Chemotaxonomy

                     Jens C. Frisvad

 

Chapter 8.    Endophytic Fungi as a Source of Novel Metabolites

                     Fernanda O. Chagas, Andrés Mauricio Caraballo-Rodriguez, and Mônica T. Pupo

 

Chapter 9.    Fungal Secondary Metabolism in the Light of Animal-Fungus Interactions: From Mechanism to Ecological Function

                     Marko Rohlfs

 

Chapter 10.  Fusarium Mycotoxins and Their Role in Plant-Pathogen Interactions

                     Gerhard Adam, Gerlinde Wiesenberger, and Ulrich Güldener

Chapter 11.  Biosynthesis and Molecular Genetics of Peptaibiotics - Fungal Peptides Containing Alpha, Alpha - Dialkyl Amino Acids

                     Xiao-Yan Song, Bin-Bin Xie, Xiu-Lan Chen, Yu-Zhong Zhang

 

O autorze

Juan-Francisco Martín, PhD
University of León, Department of Molecular Biology, Area of Microbiology, León, Spain

Carlos García-Estrada, DVM, PhD 
Institute of Biotechnology of León (INBIOTEC), Parque Científico de León, León, Spain

Susanne Zeilinger, PhD
Vienna University of Technology, Institute of Chemical Engineering, Vienna, Austria

Blurb

This book continues the exploration of fungal secondary metabolism and underlying genetics initiated in the first volume, adding analysis of regulatory key players and epigenetic control of their biosynthesis, genomics- and metabolomics-guided approaches. This work unearths the potential of fungi as resources of novel biologically active substances, the use of secondary metabolite profiles in fungal chemotaxonomy, less exploited substances and their producers, and the biological roles of secondary metabolites in organismic interactions.

 

Fungal secondary metabolites significantly impact mankind, comprising substances that contribute to human well-being such as antibiotics, antivirals, immunosuppressives, antitumor and anticholesterolemic agents. These metabolites also comprise toxins that act as virulence factors in their respective hosts, causing health problems by contaminating our food and indoor environment. For the use of beneficial substances in medicine and pharmaceutical industry and the risk reduction of fungal metabolites with adverse health effects, a detailed knowledge and understanding of fungal secondary metabolism is essential. The recent emergence of high-throughput “omics” techniques constitutes an important step in this regard and will further significantly contribute to the discovery of novel fungal metabolites.