1. Introduction: Background, state-of-art for design and development of biosensor-based techniques strategy2. Types of Biomarkers associated with cancer and other disease associated health risk factors3. Basic concept for Biosensor-based devices4. Type of Biosensors-based on Biorecognition element5. Type of Biosensors-based on transducers6. Multidisciplinary approach to device design7. Fabrication technique of Biosensor-devices 8. Lab-on-chip devices-based type of cancer cell targeting9. Challenges and future prospects and commercial viability of Biosensor-based diagnosis