Biomimetic Microengineering

ISBN-13: 9781138039131 / Angielski / Twarda / 2020 / 380 str.

Hyun Jung Kim

Opis

This book will examine the methods to reconstitute three-dimensional (3D) structure, recapitulate the human physiology as well as pathology during health and disease. A focus is on the regeneration of complex responses of our body in cells, tissues, organs, and inter-organ level interactions.

Spis treści

PART I Emulating the Microenvironment of a Living System. Emulating Biomechanical Environments in Microengineered Systems. Biomimetic Microsystems for Blood and Lymphatic Vascular Research. Multispecies Microbial Communities and Synthetic Microbial Ecosystems. PART II Enabling Technologies for Building a Biomimetic Model. Stem Cell Engineering. Organoid Technology for Basic Science and Biomedical Research.  Design, Fabrication, and Microflow Control Techniques for Organ-on-a-Chip Devices. Microfluidic Techniques for High-Throughput Cell Analysis. 3D Printing and Bioprinting Technologies. PART III Pathomimetic Disease Modeling.  Microengineered Models of Human Gastrointestinal Diseases.  Respiratory Pathophysiology - Microphysiological Models of Human Lung.  In Vitro Alzheimer’s Disease Modeling Using Stem Cells. PART IV Towards Translational Application and Precision Medicine. Manufacturing and Assembly of Micro- and Nano-scale Devices and Interfaces Using Silk Proteins.  Microarray 3D Bioprinting for Creating Miniature Human Tissue Replicas for Predictive Compound Screening.  Integration of the Immune System into Complex In Vitro Models for Preclinical Drug Development.

O autorze

Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving his Ph.D. at Yonsei University in the Republic of Korea, he did extensive postdoctoral research at both the University of Chicago and the Wyss Institute at Harvard University (under Professor Donald Ingber). These efforts resulted in cutting edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microphysiological system. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancer. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement of Precision Medicine.