Biomedical Nanotechnology: Methods and Protocols

ISBN-13: 9781493958207 / Angielski / Miękka / 2016 / 434 str.

Sarah J. Hurst

Opis

This book assembles experts from many fields to provide a practical overview of biomedical nanotechnology, from the conception of novel materials in the lab to their application in the clinic. Includes case studies, regulatory and patent information and more.

Spis treści

1. Biomedical Nanotechnology

            Sarah J. Hurst

 

Part I: Using Nanomaterials in Sensing, Imaging, and Therapeutics

 

2. Multiplexed Detection of Oligonucleotides with Biobarcoded Gold Nanoparticle Probes

            Jae-Seung Lee

 

3. Molecular Detection of Biomarkers and Cells Using Magnetic Nanoparticles and Diagnostic Magnetic Resonance

            Jered B. Haun, Tae-Jong Yoon, Hakho Lee, and Ralph Weissleder

 

4. Real-Time Quantum Dot Tracking of Single Proteins

            Jerry C. Chang and Sandra J. Rosenthal

 

5. Titanium Dioxide Nanoparticles in Advanced Imaging and Nanotherapeutics

            Tijana Rajh, Nada M. Dimitrijevic, and Elena A. Rozhkova

 

6. Surface Modification and Biomolecule Immobilization on Polymer Spheres for Biosensing Applications

            Chris R. Taitt, Lisa C. Shriver-Lake, George P. Anderson, and Frances S. Ligler

 

7. Multivalent Conjugation of Peptides, Proteins, and DNA to Semiconductor Quantum Dots

            Duane E. Prasuhn, Kimihiro Susumu, and Igor L. Medintz

 

8. A Single SnO₂ Nanowire-Based Microelectrode

            Jun Zhou, Yaguang Wei, Qin Kuang, and Zhong Lin Wang

 

9. Biosensing Using Nanoelectromechanical Systems (NEMS)

            Ashish Yeri and Di Gao

 

10. Nano “Fly Paper” Technology for the Capture of Circulating Tumor Cells

            Shutao Wang, Gwen E. Owens, and Hsian-Rong Tseng

 

11. Polymeric Nanoparticles for Photodynamic Therapy

            Yong-Eun Koo Lee and Raoul Kopelman

 

12. Hydrogel Templates for the Fabrication of Homogeneous Polymer Microparticles

            Ghanashyam Acharya, Matthew McDermott, Soo Jung Shin, Haesun Park, and Kinam Park

 

13. Antibacterial Application of Engineered Bacteriophage Nanomedicines: Antibody-Targeted, Chloramphenicol Prodrug Loaded Bacteriophages for Inhibiting the Growth of Staphylococcus aureus Bacteria

            Lilach Vaks and Itai Benhar

 

14. Viruses as Nanomaterials for Drug Delivery

            Dustin Lockney, Stefan Franzen, and Steven Lommel

 

15. Applications of Carbon Nanotubes in Biomedical Studies

            Hongwei Liao, Bhavna Paratala, Balaji Sitharaman, and Yuhuang Wang

 

16. Electrospun Nanofibrous Scaffolds for Engineering Soft Connective Tissues

            Roshan James, Udaya S. Toti, Cato T. Laurencin, and Sangamesh G. Kumbar

 

17. Peptide Amphiphiles and Porous Biodegradable Scaffolds for Tissue Regeneration in the Brain and Spinal Cord

            Rutledge G. Ellis-Behnke and Gerald E. Schneider

 

18. Computational Simulations of the Interaction of Lipid Membranes with DNA-Functionalized Gold Nanoparticles

            One-Sun Lee and George C. Schatz

 

Part II: Translating Nanoscience and Technology from the Lab to the Clinic

 

19. Cytotoxic Assessment of Carbon Nanotube Interaction with Cell Cultures

            Hanene Ali-Boucetta, Khuloud T. Al-Jamal, and Kostas Kostarelos

 

20. Nanoparticle Toxicology:  Measurements of Pulmonary Hazard Effects Following Exposures to Nanoparticles

            Christie M. Sayes, Kenneth L. Reed, and David B. Warheit

 

21. Nanoparticle Therapeutics: FDA Approval, Clinical Trials, Regulatory Pathways, and Case Study

            Aaron C. Eifler and C. Shad Thaxton

 

22. Legislating the Laboratory?: Promotion and Precaution in a Nanomaterials Company

            Robin Phelps and Erik Fisher

 

23. Navigating the Patent Landscapes for Nanotechnology: English Gardens or Tangled Grounds?

            Douglas J. Sylvester and Diana M. Bowman

 

24. Scientific Entrepreneurship in the Materials and Life Science Industries

            Jose Amado Dinglasan, Darren J. Anderson, and Keith Thomas

 

25. Applying the Marketing Mix (5 P’s) to Bionanotechnology

            Michael S. Tomczyk

 

26. Managing the “Known Unknowns”: Theranostic Cancer Nanomedicine and Informed Consent

            Fabrice Jotterand and Archie A. Alexander

Blurb

Due to their unique size-dependent properties, nanomaterials have the potential to revolutionize the detection, diagnosis, and treatment of disease by offering superior capabilities compared to conventionally-used materials.  Biomedical Nanotechnology: Methods and Protocols brings together experts from a wide variety of fields to provide a practical overview of biomedical nanotechnology, from the conception of novel materials in the laboratory to the application of such structures in the clinic. After a brief introductory chapter, the first section consists of protocol chapters which provide hands-on information on the synthesis of a variety of solution-phase and surface-bound nanomaterials and their application in sensing, imaging, and/or therapeutics, while the second section consists of a series of case studies and review chapters that discuss the toxicology of nanomaterials, the regulatory pathways to US Food and Drug Administration (FDA) approval of these materials, their patenting, marketing, and commercialization, and the legal and ethical issues surrounding their use.  Written in the highly successful Methods in Molecular Biology™ series format, many chapters include introductions to their respective topics, lists of the necessary materials, step-by-step, readily reproducible protocols, and insightful tips on troubleshooting and avoiding known pitfalls.

 

Cutting-edge and authoritative, Biomedical Nanotechnology: Methods and Protocols surveys this exciting field from the most vital angles in order to provide a comprehensive reference for scientists and researchers of all different backgrounds looking to utilize the numerous versatile applications of nanomaterial technologies.