Biomechanics of the Aorta: Modelling for Patient Care

ISBN-13: 9780323954846 / Angielski

T. Christian Gasser; Stéphane Avril; John A. Elefteriades

Opis

Biomechanics of the Aorta: Modelling for Patient Care is a holistic analysis of the aorta towards its biomechanical description. The book addresses topics such as physiology, clinical imaging, tissue and blood flow modeling, along with knowledge that is needed in diagnostics, aortic rupture prediction, assist surgical planning, and more. It encompasses a wide range of topics from the basic sciences (Vascular biology, Continuum mechanics, Image analysis) to clinical applications, as well as describing and presenting computational studies and experimental benches to mimic, understand and propose the best treatment of aortic pathologies. The book begins with an introduction to the fundamental aspects of the anatomy, biology and physiopathology of the aorta and proceeds to present the main computational fluid dynamic studies and biomechanical and mechanobiological models developed over the last decade. With approaches, methodologies and findings from contributors all over the world, this new volume in the Biomechanics of Living Organs series will increase understanding of aortic function as well as improve the design of medical devices and clinical interventions, including surgical procedures.

Spis treści

Part 1 Anatomy, Biology, Physiopathology 1. Physiopathology 2. Genetics and aortic mechanisms 3. Patho-Physiology and mechanobiology of the aortic valve 4. Mechanobiology of aortic cells 5. Clinical treatment options Part 2 Imaging and tissue/rheology characterization 6. Rheology of aortic tissue - novel methods 7. Imaging aortic flows - 4DMRI 8. US imaging for aortic biomechanics 9. Functional imaging FDG PET 10. Image processing - deep learning for model reconstruction Part 3 Tissue modelling and rupture 11. Aortic valves modelling 12. AAA and thrombus modelling 13. Aneurysm growth mechanical and biology coupled 14. Rupture modelling - novel approaches 15. Multiscale modeling from protein to aortic tissue Part 4 Flow modelling and algorithm 16. Multiphysics flow modeling in the aorta 17. Novel approaches in FSI for the aorta 18. Turbulence modeling of blood flow 19. Inverse problems in aortic flow modelling 20. Modeling of Flow induced mechanosignaling 21. Reduced order modeling

Part 5 Applications 22. TAVI aortic valve 23. AAA rupture prediction 24. (T)EVAR simulation 25. FSI in aortic dissections 26. Biomechanics of drug treatment 27. Artificial Intelligence-based approaches