Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects

ISBN-13: 9780081029060 / Angielski / Miękka / 2020 / 690 str.

Nihal Vrana; Helena Knopf-Marques; Julien Barthes

Spis treści

1. Introduction

Section 1: Biomaterials
2. Classes of Biomaterials used in Tissue/Organ Regeneration
3. Physicochemical Properties of Biomaterials
4. Synthesis or Modification of Biomaterials for Regenerative Medicine Applications
5. Surface Modifications of Biomaterials for Tissue Engineering

Section 2: Cell microenvironment and signalling
6. Cell microenvironment and ECM
7. Cell signalling and strategies to modulate cell behaviour

Section 3: Cells
8. Stem cells: sources, properties and cell types
9. Tissue specific cells: sources, properties and cell types
10. Cell differentiation: sources, properties and cell types
11. Immune cells: sources, properties and cell types
12. Angiogenesis/vascular cells: sources, properties and cell types

Section 4: Organ specific Artificial tissues/Organs
13. Heart/Cardiovascular tissues
14. Respiratory system tissues
15. Digestive system tissues
16. Kidney Tissue Engineering
17. Liver Tissue Engineering
18. Pancreas Tissue Engineering
19. Neural Tissue Engineering
20. Musculoskeletal Tissue engineering

Section 5: Biotechnological approaches and Enabling technologies related to organ regeneration
21. Emerging biotechnological approaches with respect to organ regeneration: SiRNA, miRNA, CRISPR, CAR-T therapy, -omics approaches etc.
22. Bioreactors
23. On-chip organ systems
24. In vitro disease and organ models
25. Bioprinting
26. Biorobotics
27. Imaging techniques for biomaterials, stem cells and engineered tissues/organs
28. Future perspectives/Industrialisation and Up-scaling of organ regeneration technologies

O autorze

Nihal Vrana is Co-founder of SPARTHA Medical. He holds B.Sc. (Biology) and M.Sc. (Biotechnology) degrees from Middle East Technical University. He obtained his PhD at Dublin City University as a Marie Curie ESR fellow. His major research interests are titanium and silicone implants, tissue engineering, cell encapsulation, antimicrobial surfaces, multifunctional coatings, immunomodulation, real-time monitoring of implants, biomaterial risk assessment and cell biomaterials interactions. He has coordinated 2 multi-partner, multinational EU projects (BiMot and IMMODGEL (www.immodgel.com)) and is currently coordinating a H2020 project (PANBioRA, www.panbiora.eu). Helena Knopf-Marques is a Senior Researcher at PROTiP Medical. She has also been associate professor at Strasbourg University. She has been working with the development of new biomaterials since her graduation. She is a Chemical Engineer with a masters in Mechanical Engineering. She received her PhD from the Program in Metallurgical and Materials Engineering at Federal University of Rio de Janeiro. Her main research interests are tissue engineering, multifunctional coatings, immunomodulation of biomaterial surfaces, 3D printing and cell biomaterial interactions. She is presently working on the EU Horizon 2020 project PANBioRA that aims to develop new instruments for biomaterials characterization and risk assessment. Dr. Julien Barthes is collaborative Project Manager at PROTiP MEDICAL. He holds two master's degrees in physical/chemical properties of polymers and in polymer science (ECPM, Strasbourg). He obtained in PhD in 2014 at Strasbourg in Inserm (French National Institute of Health and Medical Research) in "Biomaterials and Bioengineering” department His main research areas are hydrogel development, titanium implants, tissue engineering, cell biomaterials interactions, release of bioactive molecules in cell microenvironment and 3D printing. He is a scientific contributor in Horizon 2020European Project (PANBioRA) about biomaterial risk assessment. He is also in charge of the development of patient specific 3D printed medical implant from bench to market.