Biomarkers in Neoplastic Neuropathology

ISBN-13: 9783319793214 / Angielski / Miękka / 2018 / 98 str.

Fausto Rodriguez; Cheng-Ying Ho

Spis treści

Introduction.- Special Techniques.- Biobanking and Regulations.- Public Databases.- Biomarkers applied to specific tumor types.- Conclusions.

O autorze

Fausto Rodriguez

John Hopkins University

Dept. of Pathology

Baltimore, MD

USA

Cheng-Ying Ho

Children's National Medical Center

Dept. of Pathology

Washington, DC

USA

Blurb

This book is a rich source of information on biomarkers applicable to the pathology of neoplastic disorders of the brain. Thorough descriptions are provided of the techniques currently available for clinical and experimental evaluation of biomarkers in brain neoplasms, including in situ hybridization, array-based methods, methylation profiling, next-generation sequencing, and practical gene panels. Incorporation of multiple biomarkers in the development of molecular subgroups with biologic and therapeutic relevance is also discussed. A section on biobanking covers the equally important topic of optimal preservation of tissue and includes consideration of ethical considerations raised by the use of tissue obtained in clinical settings. The closing section discusses the major categories of neoplastic disorders involving the nervous system, with emphasis on diagnostic, prognostic, and predictive biomarkers used in the pathologic evaluation of different types of brain tumor.