Biomarkers in Diabetes

ISBN-13: 9783031080135 / Angielski / Twarda / 2022 / 1175 str.

Vinood B. Patel;Victor R. Preedy

Opis

This handbook focuses specifically on biomarkers in diabetes and provides a comprehensive understanding of this field. Readers will gain deep insights into bioinformatics and network analysis of biomarkers in diabetes, and will learn about circulating biomarkers in body fluids and specific pathological features of diabetes. Various animal models in diabetes research are also presented. In addition, like the previous volumes in this large reference series, the book provides a comprehensive look at genetics, cellular, and histological variables. The goal of this handbook is to provide information on markers of this disease to facilitate diagnosis, introduce new technologies, and ultimately improve health. It is a must for researchers as well as advanced students and physicians in the field of diabetes and biomarker research and application.

Spis treści

Bioinformatics and biomarkers for diabetes.- Network analysis of biomarkers un diabetes.-Biomarkers of insulin action .-Circulating and body fluid biomarkers -glucose.-Fructosamine as a glycaemic marker: features and applications.-Postload plasma glucose and oral glucose tolerance tests (OGTT): applications.- Circulating and body fluid biomarkers -impact of diabetes on pathology.- Biomarkers of diet in relation to diabetes: 5-CIS-, trans-and total lycopene.- Fatty Acid Biomarkers and Type 2 Diabetes.- Biomarkers of retina-related disease in diabetes.-Biomarkers of diabetes-induced nephropathy.- Biomarkers of atherosclerosis in diabetes mellitus.- Advanced glycation end products as biomarkers in diabetes.- Biomarkers of vascular injury in diabetes.- Amino acids as a biomarkers in diabetes .-Adiponectin-leptin ratio and diabetes.- Plasma omentin-1 as a biomarker in type 2 diabetes.- Serpin A12 as a type 2 diabetes biomarker.-Circulating Hsp90 as a potential biomarker of beta cell autoimmunity in type 1 diabetes.-CUBN variants, HES1, CDC73 and GRM5 as biomarkers in diabetes.-Biomarker polymorphisms and diabetic patients.- Epigenetics and 5-Hydroxymethylcytosines as a biomarker in type 2 diabetes. - Longevity biomarkers and applications to diabetes   

O autorze

Vinood B. Patel, BSc, PhD, FRSC, is currently a Reader in Clinical Biochemistry at the University of Westminster and honorary fellow at King’s College London. He presently directs studies on metabolic pathways involved in liver disease, particularly related to mitochondrial energy regulation and cell death. Research is being undertaken to study the role of nutrients, antioxidants, phytochemicals, iron, alcohol and fatty acids in the pathophysiology of liver disease. Other areas of interest are identifying new biomarkers that can be used for the diagnosis and prognosis of liver disease and understanding mitochondrial oxidative stress in Alzheimer’s disease and gastrointestinal dysfunction in autism. Dr Patel graduated from the University of Portsmouth with a degree in Pharmacology and completed his PhD in protein metabolism from King’s College London in 1997. His postdoctoral work was carried out at Wake Forest University Baptist Medical School studying structural-functional alterations to mitochondrial ribosomes, where he developed novel techniques to characterize their biophysical properties. Dr Patel is a nationally and internationally recognized researcher and was involved in several NIH-funded biomedical grants related to alcoholic liver disease. Dr Patel has edited biomedical books in the area of toxic agents (alcohol), nutrition and health prevention, and biomarkers and has published over 150 articles, and in 2014, he was elected as a Fellow to The Royal Society of Chemistry.

Victor R. Preedy BSc, PhD, DSc, FRSB, FRSPH, FRCPath, FRSC is a senior member of King's College London. He is also Director of the Genomics Centre and a member of the Faculty of Life Sciences and Medicine. Professor Preedy graduated in 1974 with an Honours Degree in Biology and Physiology with Pharmacology. He gained his University of London PhD in 1981. In 1992, he received his Membership of the Royal College of Pathologists and in 1993 he gained his second doctoral degree, for his outstanding contribution to protein metabolism in health and disease. Professor Preedy was elected as a Fellow to the Institute of Biology in 1995 and to the Royal College of Pathologists in 2000. Since then he has been elected as a Fellow to the Royal Society for the Promotion of Health (2004) and The Royal Institute of Public Health (2004). In 2009, Professor Preedy became a Fellow of the Royal Society for Public Health and in 2012 a Fellow of the Royal Society of Chemistry. In his career Professor Preedy has carried out research at the National Heart Hospital (part of Imperial College London), The School of Pharmacy (now Part of University College London) and the MRC Centre at Northwick Park Hospital. He has collaborated with research groups in Finland, Japan, Australia, USA and Germany. He is a leading expert on the science of health and has a long standing interest in biomarkers for over 30 years especially related to tissue pathology. He has lectured nationally and internationally. To his credit, Professor Preedy has published over 600 articles, which includes peer-reviewed manuscripts based on original research, abstracts and symposium presentations, reviews and numerous books and volumes.