Biology and Physiology of the Blood-Brain Barrier: Transport, Cellular Interactions, and Brain Pathologies

ISBN-13: 9780306453625 / Angielski / Twarda / 1996 / 388 str.

Pierre-O Couraud; Pierre-Olivier Couraud; Daniel Scherman

Opis

The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho- logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than 50 participants. including investigators in basic neuroscience, physicians. and stu- dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.

Spis treści

Introductory Overviews: Development of Blood-Brain Barrier Endothelial Cells; W. Risau. Prospects of Neuroprotective Gene Therapy for Neurodegenerative Diseases; M. Peschanski. Physiological Transports through the Blood-Brain Barrier: Blood-Brain Taurine Transport and Brain Volume Regulation; R.F. Keep; et al. Volume Regulation of the in vitro Blood-Brain Barrier by Osmoreactive Amino Acids during Stress; P.J. Gaillard, et al. Blood-Brain Barrier and Drug Delivery to the Brain: The Microarchitecture of Cerebral Vessels; K.R. Davies, et al. Development of Blood-Brain Barrier Tight Junctions; U. Kniesel, et al. Multidrug Resistance Pglycoprotein at the Blood-Brain Barrier: Functional Expression of Multidrug Resistance P-glycoprotein in Cellular Models of Physiological Barriers; D. Lechardeur, et al. A Method to Assess Functional Activity of Pglycoprotein in vitro Based on the Energy Requirements of the Transporter; A. Reichel, et al. Brain Pathologies and Blood-Brain Barrier: Identification of the Penumbra in an Ischemic Rat Model by MRI after Injection of a Superparamagnetic Contrast Agent; D. Ibarrola, et al. Effects of Hypoxia on an in vitro Blood-Brain Barrier; M. Plateel, et al. 44 additional articles. Index.