Biologically Active Small Molecules: Modern Applications and Therapeutic Perspectives

ISBN-13: 9781774910689 / Angielski / Twarda / 2023 / 368 str.

Mahapatra, Debarshi Kar

Opis

Focuses on small molecules as active pharmacological agents, their pharmacotherapeutically active properties, new approaches in drug discovery using small molecules, and biopharmaceutic approaches for low molecular weight ligands.

Spis treści

PART I: Small Molecules as Active Pharmacological Agents 1. Bedaquiline: The New Antituberculosis Drug on the Horizon 2. Plant-Derived Natural Products as Antiglycating Agents 3. Perspectives of Chalcone-Based Nf-Κβ Inhibitors as Anti-Inflammatory Agents 4. Coronaviruses: Molecular Modeling and Docking Studies of Potential Drug Candidates Showing Anti-Covid-19 Activity PART II: Pharmacotherapeutically Active Classes 5. Perspectives on Local Anesthetics in Medicine 6. Pharmacotherapeutic Perspectives on Adrenergic Agonists 7. Therapeutic Perspectives of Adrenergic Antagonists 8. Skeletal Muscle Relaxants: Concepts and Developments 9. Nonsteroidal Anti-Inflammatory Drugs: Concepts and Innovations PART III: Modern Approaches in Small Molecule Drug Discovery 10. Biological Databases: Tool for Low Molecular Weight Ligand Discovery Process 11. High-Throughput Screening Technique: Role in the Drug Discovery of Low Molecular Weight Ligands 12. Homology Modeling: Applications in the Low Molecular Weight Ligand Designing PART IV: Biopharmaceutics Approaches for Low Molecular Weight Ligands 13. Drug Metabolism: Detoxification and Xenobiotic Biotransformation 14. Drug Interactions: Highlights of Adverse Effects of Low Molecular Weight Ligands PART V: Evaluation Methods for Small Molecules 15. Low Molecular Weight Antioxidant Agents and Model for Their Evaluation