Biologically Active Natural Products: Pharmaceuticals

ISBN-13: 9780849318870 / Angielski / Twarda / 1999 / 296 str.

Stephen J. Cutler; Horace G. Cutler

Opis

This text demonstrates the connections between agrochemicals and pharmaceuticals, and explores the use of plants and plant products in the formulation and development of pharmaceuticals. It also discusses the fractionation of plants to discover substances that combat cancer; presents structure-activity relationships of antimalarials; and includes plant-derived products and their analogues, with antitumour, anti-HIV and antifungal activity.

Recenzje

"…its chapters are well referenced…index covers the compounds presented in each chapter…Pharmacy schools that have active natural products programs should purchase this book for its library…faculty, post-doctral fellows and senior graduate students should consider it for personal purchase."
--American Journal of Pharmaceutical Education, Vol. 64

Spis treści

Connections between Agrochemicals and Pharmaceuticals. Fractionation of Plants to Discover Substances to Combat Cancer. Therapetuic Potential of Plant-Derived Compounds: Realizing the Potential. Biodiversity Conservation, Economic Development, and Drug Discovery in Suriname. Recent Trends in the Use of Natural Products and Their Derivatives as Potential Pharmaceutical Agents. Highlights of Research on Plant-Derived Natural Products and Their Analogs with Antitumor, Anti-HIV, and Antifungal Activity. Discovery of Antifungal Agents from Natural Sources: Virulence Factor Targets. Reactive Quinones: From Chemical Defense Mechanisms in Plants to Drug Design. Structure-Activity Relationships of Peroxide Based Artemisinin Antimalarials. Naturally Occurring Antimutagenic and Cytoprotective Agents. Lobeline: A Natural Product with High Affinity for Neuronal Nicotinic Receptors and a Vast Potential for Use in Neurological Disorders. Protein Kinase C Inhibitory Phenylpropanoid Glycosides from Polygonum Species. Thwarting Resistance: Annonaceous Acetogenins as New Pesticidal and Antitumor Agents. A Strategy for Rapid Identification of Novel Therapeutic Leads from Natural Products. Dynamic Docking Study of the Binding of 1-Chloro-2, 4-Dinitrobenzene in the Putative Electrophile Binding Site of Naturally Occurring Human Glutathione S-Transferase Pi Allelo-Polymorphic Proteins. Panax Ginseng: Standardization and Biological Activity. Marine Natural Products as Leads to Develop New Drugs and Insecticides. Commercialization of Plant-Derived Natural Products as Pharmaceuticals: A View from the Trenches.

O autorze

Stephen J. Cutler, Horace G. Cutler