Biological Safety: Principles and Practices

ISBN-13: 9781555816209 / Angielski / Twarda / 2016 / 741 str.

Kenneth Ed. Ellis

Opis

Good science is safe science Biological safety and biosecurity protocols are essential to the reputation and responsibility of every scientific institution, whether research, academic, or production. Every risk--no matter how small--must be considered, assessed, and properly mitigated. If the science is not safe, it is not good science. Now in its fifth edition, Biological Safety: Principles and Practices remains the most comprehensive biosafety reference. This book presents the guiding principles of laboratory safety, including the identification, assessment, and control of the broad variety of risks encountered in laboratories, production facilities, classrooms, and other unique environments. Specifically, Biological Safety covers

• protection and control elements, ranging from biological safety cabinets and personal protection systems to workplace practices and decontamination methods
• administrative controls in biorisk management, including regulations, guidelines, and compliance
• various aspects of risk assessment, including bacterial, viral, mycotic, zoonotic, and molecular agents; protozoa and helminthes; viral vectors, allergens, and toxins; and decontamination, aerobiology, occupational medicine, and training topics

A resource for biosafety professionals, instructors, and those who work with pathogenic agents in any capacity, Biological Safety is also a critical reference for laboratory managers and those responsible for managing biohazards in a range of settings, including basic and agricultural research, clinical laboratories, the vivarium, field study, insectories, and greenhouses.

Spis treści

IntroductionContributors ixForeword--Caryl P. Griffin and James Welch xiiiPreface xvSection I. Hazard identification1. The Microbiota of Humans and Microbial Virulence Factors 3Paul A. Granato2. Indigenous Zoonotic Agents of Research Animals 19Lon V. Kendall3. Biological Safety Considerations for Plant Pathogens and Plant-Associated Microorganisms of Significance to Human Health 39Anne K. Vidaver, Sue A. Tolin, and Patricia Lambrecht4. Laboratory-Associated Infections 59Karen Brandt Byers and A. Lynn HardingSection II. Hazard assessment5. Risk Assessment of Biological Hazards 95Dawn P. Wooley and Diane O. Fleming6. Protozoa and Helminths 105Barbara L. Herwaldt7. Mycotic Agents 147Wiley A. Schell8. Bacterial Pathogens 163Travis R. McCarthy, Ami A. Patel, Paul E. Anderson, and Deborah M. Anderson9. Viral Agents of Human Disease: Biosafety Concerns 187Michelle Rozo, James Lawler, and Jason Paragas10. Emerging Considerations in Virus-Based Gene Transfer Systems 221J. Patrick Condreay, Thomas A. Kost, and Claudia A. Mickelson11. Biological Toxins: Safety and Science 247Joseph P. Kozlovac and Robert J. Hawley12. Molecular Agents 269Dawn P. Wooley13. Biosafety for Microorganisms Transmitted by the Airborne Route 285Michael A. Pentella14. Cell Lines: Applications and Biosafety 299Glyn N. Stacey and J. Ross Hawkins15. Allergens of Animal and Biological Systems 327Wanda Phipatanakul and Robert A. WoodSection III. Hazard Control16. Design of Biomedical Laboratory and Specialized Biocontainment Facilities 343Jonathan T. Crane and Jonathan Y. Richmond17. Primary Barriers and Equipment-Associated Hazards 367Elizabeth Gilman Duane and Richard C. Fink18. Primary Barriers: Biological Safety Cabinets, Fume Hoods, and Glove Boxes 375David C. Eagleson, Kara F. Held, Lance Gaudette, Charles W. Quint, Jr., and David G. Stuart19. Arthropod Vector Biocontainment 399Dana L. Vanlandingham, Stephen Higgs, and Yan-Jang S. Huang20. Aerosols in the Microbiology Laboratory 411Clare Shieber, Simon Parks, and Allan Bennett21. Personal Respiratory Protection 425Nicole Vars McCullough22. Standard Precautions for Handling Human Fluids, Tissues, and Cells 443Debra L. Hunt23. Decontamination in the Microbiology Laboratory 463Matthew J. Arduino24. Packing and Shipping Biological Materials 475Ryan F. Relich and James W. SnyderSection IV. Administrative Control25. Developing a Biorisk Management Program to Support Biorisk Management Culture 495LouAnn C. Burnett26. Occupational Medicine in a Biomedical Research Setting 511James M. Schmitt27. Measuring Biosafety Program Effectiveness 519Janet S. Peterson and Melissa A. Morland28. A ""One-Safe"" Approach: Continuous Safety Training Initiatives 537Sean G. Kaufman29. Biosafety and Biosecurity: Regulatory Impact 551Robert J. Hawley and Theresa D. Bell TomsSection V. Special Environments30. Biological Safety and Security in Teaching Laboratories 565Christopher J. Woolverton and Abbey K. Woolverton31. Biosafety in the Pharmaceutical Industry 585Brian R. Petuch32. Biosafety Considerations for Large-Scale Processes 597Mary L. Cipriano, Marian Downing, and Brian R. Petuch33. Veterinary Diagnostic Laboratories and Necropsy 619Timothy Baszler and Tanya Graham34. Special Considerations for Animal Agriculture Pathogen Biosafety 647Robert A. Heckert, Joseph P. Kozlovac, and John T. Balog35. Biosafety of Plant Research in Greenhouses and Other Specialized Containment Facilities 665Dann Adair, Sue Tolin, Anne K. Vidaver, and Ruth Irwin36. Biosafety Guidelines for Working with Small Mammals in a Field Environment 679Darin S. Carroll, Danielle Tack, and Charles H. Calisher37. Components of a Biosafety Program for a Clinical Laboratory 687Michael A. Pentella38. Safety Considerations in the Biosafety Level 4 Maximum-Containment Laboratory 695David S. Bressler and Robert J. HawleyIndex 719