Biological Membrane Ion Channels: Dynamics, Structure, and Applications

ISBN-13: 9781441922076 / Angielski / Miękka / 2010 / 658 str.

Shin-Ho Chung; Olaf S. Anderson; Vikram V. Krishnamurthy

Opis

Ion channels are biological nanotubes that are formed by membrane proteins. Because ion channels regulate all electrical activities in living cells, understanding their mechanisms at a molecular level is a fundamental problem in biology. This book deals with recent breakthroughs in ion-channel research that have been brought about by the combined effort of experimental biophysicists and computational physicists, who together are beginning to unravel the story of these exquisitely designed biomolecules. With chapters by leading experts, the book is aimed at researchers in nanodevices and biosensors, as well as advanced undergraduate and graduate students in biology and the physical sciences. Key Features

• Presents the latest information on the molecular mechanisms of ion permeation through membrane ion channels
• Uses schematic diagrams to illustrate important concepts in biophysics
• Written by leading researchers in the area of ion channel investigations

Spis treści

Historical Overview. -Tutorial on Transmembrane Currents and Ion Channels. -Structural and Functional Properties of Ion Channels. -Atomic Structures of Ion Channels. -Gramicidin Channels. -Potassium Channels. -Voltage-Gated Channels. -ClC Chloride Channels. -Sodium Channels. -Calcium Channels. -Mechano-Sensitive Channels. -Ligand-Gated Channels. -Dynamics of Ion Channels. -Poisson-Nernst-Planck Theory. -Semi-Microscopic Monte Carlo Method. -Brownian Dynamics. -Molecular Dynamics. -Emerging Technologies. -Microchip Technology in Ion Channel Research. -Biosensors. -Signal Processing with Hidden Markov Models.