Biologic Knee Reconstruction: A Surgeon's Guide

ISBN-13: 9781617118166 / Angielski / Twarda / 2015 / 280 str.

Brian Cole; Joshua Harris

Opis

Treatment of articular cartilage pathology in the knees of young and active patients is a challenging and controversial issue. Biologic Knee Reconstruction: A Surgeon's Guide is a how-to, step-by-step guide that addresses the evaluation and management of this unique patient population.

Internationally renowned cartilage experts Dr. Brian J. Cole and Dr. Joshua D. Harris, along with their contributors, present information on normal and abnormal history and physical examination. The reader will learn proper decision-making using a patient-centered approach of treatment, increasing the likelihood of a successful outcome. In addition to radiographic assessment of articular cartilage, Biologic Knee Reconstruction discusses the use of biomarkers, defect classification, and patient-reported and surgeon-measured outcomes. Aggressive nonsurgical medical management, including medications, injections, physiotherapy, and rehabilitation, is also presented.

Biologic Knee Reconstruction also discusses the management of concomitant pathologies such as malalignment, meniscal deficiency, and ligamentous instability. Selection of surgical cartilage restorative treatment options is multifactorial, requiring consideration of several patient-, knee-, and defect-specific issues. All contemporary open and arthroscopic cartilage techniques are presented in detail with high resolution figures. A unique feature of Biologic Knee Reconstruction is the presentation of several chapters discussing non-medical issues highly pertinent to the advancement and future of this field: funding of research and cost of new advanced technologies, regulation of advanced cellular, tissue, and genetic technologies, evidence-based medicine and clinical trial design and conduct, and the ethics of allograft tissues and stem cell use.

Features:

• Technique preference cards from the experts performing cartilage surgery
• Patient education information
• The most up-to-date descriptions of advanced cartilage techniques
• Unique chapters not covered in books elsewhere, including:
  • Biomarkers
  • Patient-reported outcomes assessment
  • Newer injection techniques (PRP, stem cells)
  • One- and two-stage open and arthroscopic techniques using chondrocyte- and stem cell based cell therapies
  • Costs and public and private funding of research
  • Barriers to high-quality randomized trials
  • Governmental regulation and availability/accessibility to patients
  • Gene therapy and tissue engineering
  • Ethics of articular cartilage surgery with stem cells, ex-vivo cell manipulation, and juvenile tissue sources
  
  With the most up-to-date content and step-by-step methods for surgical procedures, Biologic Knee Reconstruction: A Surgeon's Guide is the perfect addition to the bookshelf of the orthopedic surgeon, cartilage researcher, sports physical therapist, or athletic trainer who evaluates and manages this unique patient population.

Spis treści

Dedication
Acknowledgments 
About the Editors
Contributing Authors 
Foreword by Lars Peterson, MD, PhD 

Section I Introduction 
Chapter 1 Articular Cartilage and Subchondral Bone Anatomy and Physiology
Jason J. Shin, MD; Adam B. Yanke, MD; and Nikhil N. Verma, MD
Chapter 2 Articular Cartilage and Subchondral Bone Pathology 
Brian Chilelli, MD; Gloria Matthews, DVM, PhD; Tom Minas, MD; and Andreas H. Gomoll, MD
Chapter 3 Patient Evaluation: History and Physical Examination 
Michael B. Ellman, MD and Charles A. Bush-Joseph, MD
Chapter 4 Preoperative Articular Cartilage and Subchondral Bone Imaging 
Amit Gupta, MD; Michael C. Forney, MD; and Carl S. Winalski, MD
Chapter 5 Postoperative Articular Cartilage and Subchondral Bone Imaging 
Michael C. Forney, MD; Amit Gupta, MD; and Carl S. Winalski, MD
Chapter 6 Biomarkers in Early and Post-Traumatic Osteoarthritis 
Ariel M. Bodker, MD; Christian Lattermann, MD; and Susan Chubinskaya, PhD
Chapter 7 Chondral and Osteochondral Defect Classification 
Jonathan M. Frank, MD and Bernard R. Bach Jr, MD
Chapter 8 Patient- and Surgeon-Reported Outcomes Assessment 
Brandon Beamer, MD and Frank McCormick, MD

Section II Nonsurgical Treatment 
Chapter 9 Pharmacological Treatments 
Julia Bruene, MD and Kathleen Weber, MD, MS
Chapter 10 Rehabilitation and Physiotherapy 
Brandon Johnson, MD and Bert R. Mandelbaum, MD, DHL (Hon)

Section III Cartilage Palliation Techniques
Chapter 11 Debridement and Chondroplasty for Focal Chondral Defects
Sanjeev Bhatia, MD; Rachel M. Frank, MD; and Brian Forsythe, MD

Section IV Cartilage Repair Techniques 
Chapter 12 Subchondral Bone Treatment
Geoffrey D. Abrams, MD; Joshua D. Harris, MD; and Brian J. Cole, MD, MBA 
Chapter 13 Internal Fixation for Chondral and Osteochondral Lesions 
Ryan J. McNeilan, MD; David C. Flanigan, MD; and Kyle Randall, MD
Chapter 14 Microfracture, Nanofracture, PowerPick, and Abrasion Arthroplasty 
Ethan Kellum, MD, MS and Kai Mithoefer, MD
Chapter 15 Enhanced Marrow-Stimulation Techniques 
Rachel M. Frank, MD; Kai Mithoefer, MD; Sanjeev Bhatia, MD; and Brian J. Cole, MD, MBA

Section V Cartilage Restoration Techniques: Cell-Based Therapies
Chapter 16 Osteochondral Autograft
Adam S. Wilson, MD and Mark D. Miller, MD
Chapter 17 Fresh Osteochondral Allograft 
Joshua D. Harris, MD and Brian J. Cole, MD, MBA
Chapter 18 Autologous Chondrocyte Implantation 
Andreas H. Gomoll, MD
Chapter 19 Other Chondrocyte-Based Cell Therapies 
Giuseppe Filardo, MD, PhD; Luca Andriolo, MD; Elizaveta Kon, MD; and Maurilio Marcacci, MD, Prof
Chapter 20 Stem Cell-Based Cell Therapies 1
Elizaveta Kon, MD; Alice Roffi, BSc; Giuseppe Filardo, MD, PhD; and Maurilio Marcacci, MD, Prof

Section VI Combined Techniques: Biologic Knee Reconstruction 
Chapter 21 Malalignment—Varus—High Tibial Osteotomy 
Francesca de Caro, MD and Annunziato Amendola, MD
Chapter 22 Malalignment—Valgus—Distal Femoral Osteotomy
Gregory A. Sawyer, MD and Robert F. LaPrade, MD, PhD
Chapter 23 Proximal and Distal Patellofemoral Surgery 
Jack Farr, MD and Andreas H. Gomoll, MD
Chapter 24 Meniscal Deficiency: Repair and Transplantation 
Peter N. Chalmers, MD; Robert A. Sershon, MD; and Brian J. Cole, MD, MBA

Section VII The Future of Articular Cartilage Surgery
Chapter 25 Costs and Research Funding: Public and Private Sources 
Geoffrey S. Van Thiel, MD, MBA and Brian J. Cole, MD, MBA
Chapter 26 Governmental Regulation and Availability and Accessibility to Patients 
Jonathan A. Godin, MD, MBA and Richard C. Mather III, MD, MBA
Chapter 27 Barriers to High-Quality Randomized Trials: Noninferiority to Superiority 
Jaskarndip Chahal, MD, MSc, FRCSC and Ken Zaslav, MD
Chapter 28 Gene Therapy and Tissue Engineering 
Laurie R. Goodrich, DVM, PhD, Diplomate ACVS
Chapter 29 Ethics of Articular Cartilage Surgery: Stem Cells, Ex Vivo Manipulation, and Juvenile Sources
H. Davis Adkisson, PhD; Philip R. Streeter, PhD; Kevin F. Bonner, MD; and Joseph Feder, PhD

Financial Disclosures
Index