Biodefense Research Methodology and Animal Models

ISBN-13: 9780367381677 / Angielski / Miękka / 2019 / 415 str.

James R. Swearengen

Opis

Since the publication of the first edition of this volume, significant advances have been made in animal model development for biological research and the ramifications of the FDA’s Animal Efficacy Rule have become better understood in the scientific community. With each chapter completely updated with the latest research findings, this volume spans the spectrum of coverage from basic research to advanced development of medical countermeasures. Topics discussed include a history of biological agents as weapons, concepts and strategies involved in biowarfare and bioterrorism, animal models in biodefense research, and infectious disease aerobiology. The book also presents studies involving a range of specific diseases and toxins.

Spis treści

History of Biological Agents as Weapons. Bioterrorism and Biowarfare: Similarities and Differences. Scientific and Ethical Importance of Animal Models in Biodefense Research.Development and Validation of Animal Models.Infectious Disease Aerobiology: Aerosol Challenge Methods. Characterization of New and Advancement of Existing Animal Models of Bacillus anthracis Infection. Glanders. Plague. Tularemia. Q Fever. Brucellosis. Alphaviruses. Orthopoxviruses. Animal Models for Viral Hemorrhagic Fevers. Botulinum Toxins. Ricin. Staphylococcal and Streptococcal Superantigens: In Vitro and In Vivo Assays. Index.

O autorze

Dr. James R. Swearengen, following retirement from the U.S. Army after 21 years of service, served for 4 years as the senior director at the Association for Assessment and Accreditation of Laboratory Animal Care International before joining the National Biodefense Analysis and Countermeasures Center as their comparative medicine veterinarian in 2009. Since 2007, Dr. Swearengen has served on the National Academies of Science National Research Council Standing Committee on Biodefense for the U.S. Department of Defense and the National Academies of Science Institute for Laboratory Animal Research Committee on Animal Models for Assessing Countermeasures to Bioterrorism Agents.