Bioconjugates

ISBN-13: 9781118359143 / Angielski / Twarda / 2014 / 496 str.

Ravin Narain

Opis

Explores bioconjugate properties and applications of polymers, dendrimers, lipids, nanoparticles, and nanotubes Bioconjugation has enabled breakthroughs across many areas of industry and biomedicine. With its emphasis on synthesis, properties and applications, this book enables readers to understand the connection between chemistry and the biological application of bioconjugated materials. Its detailed descriptions of methods make it possible for researchers to fabricate and take full advantage of bioconjugates for a broad range of applications. Moreover, the book sets the foundation for the development of new applications, including assays, imaging, biosensors, drug delivery, and diagnostics. Chemistry of Bioconjugates features contributions from an international team of leading experts and pioneers in the field. These contributions reflect the authors' firsthand laboratory experience as well as a thorough review of the current literature. The book's six sections examine:

• General methods of bioconjugation
• Polymer bioconjugates
• Organic nanoparticle-based bioconjugates
• Inorganic nanomaterial bioconjugates, including metals and metal oxides
• Cell-based, hydrogel/microgel, and glyco-bioconjugates
• Characterization, physico-(bio)chemical properties, and applications of bioconjugates

This comprehensive exploration of bioconjugates includes discussions of polymers, dendrimers, lipids, nanoparticles, and nanotubes. References at the end of each chapter serve as a gateway to the most important original research findings and reviews in the field. By drawing together and analyzing all the latest chemical methods and research findings on the physico-chemical and biochemical properties of bioconjugates, Chemistry of Bioconjugates sheds new light on the significance and potential of bioconjugation. The book is recommended for organic and polymer chemists, biochemists, biomaterial scientists, carbohydrate chemists, biophysicists, bioengineers, and drug and gene delivery scientists.

Spis treści

PREFACE vii

CONTRIBUTORS ix

SECTION I GENERAL METHODS OF BIOCONJUGATION

1 Covalent and Noncovalent Bioconjugation Strategies 3
Rajesh Sunasee and Ravin Narain

SECTION II POLYMER BIOCONJUGATES

2 Bioconjugates Based on Poly(Ethylene Glycol)s and Polyglycerols 79
Rajesh A. Shenoi, Fang Gao, Muhammad Imran ul–Haq, and Jayachandran N. Kizhakkedathu

3 Synthetic Polymer Bioconjugate Systems 104
Marya Ahmed and Ravin Narain

4 Natural Polymer Bioconjugate Systems 133
Lichao Liu, Xiuwei Pan, and Weian Zhang

5 Dendrimer Bioconjugates: Synthesis and Applications 146
Ali Nazemi and Elizabeth R. Gillies

SECTION III ORGANIC NANOPARTICLES BASED BIOCONJUGATES

6 Bioconjugation Strategies: Lipids, Liposomes, Polymersomes, and Microbubbles 187
Anirban Sen Gupta and Horst A. von Recum

7 Organic Nanoparticle Bioconjugate: Micelles, Cross–Linked Micelles, and Nanogels 203
Maria Vamvakaki

8 Carbon Nanotubes and Fullerene C60 Bioconjugates 239
Keshwaree Babooram and Ravin Narain

SECTION IV INORGANIC NANOMATERIALS BIOCONJUGATES (METALS, METAL OXIDES QUANTUM DOTS, IRON–OXIDE)

9 Gold Nanomaterials Bioconjugates 257
Qian Yang

10 Methods for Magnetic Nanoparticle Synthesis and Functionalization 281
Mohammad H. El–Dakdouki, Kheireddine El–Boubbou, Jingguang Xia, Herbert Kavunja, and Xuefei Huang

11 Quantum Dots Bioconjugates 315
Xiaoze Jiang, Meifang Zhu, and Ravin Narain

12 Silica Nanoparticle Bioconjugates 327
Yohei Kotsuchibashi, Mitsuhiro Ebara, and Ravin Narain

13 Polyhedral Oligomeric Silsesquioxanes (POSS) Bioconjugates 344
Weian Zhang, Zhenghe Zhang, and Lizhi Hong

SECTION V CELL–BASED, HYDROGELS/MICROGELS AND GLYCO–BIOCONJUGATES

14 Cell–Based Bioconjugates 357
Mitsuhiro Ebara

15 Bioresponsive Hydrogels and Microgels 370
Xue Li and Michael J. Serpe

16 Conjugation Strategies Used for the Preparation of Carbohydrate–Conjugate Vaccines 387
Rachel Hevey and Chang–Chun Ling

SECTION VI CHARACTERIZATION, PHYSICO–(BIO)CHEMICAL PROPERTIES, AND APPLICATIONS OF BIOCONJUGATES

17 Properties and Characterization of Bioconjugates 417
Ali Faghihnejad, Jun Huang, and Hongbo Zeng

18 Physico–Chemical and Biochemical Properties of Bioconjugates 431
Marya Ahmed and Ravin Narain

19 Applications of Bioconjugates 444
Marya Ahmed and Ravin Narain

INDEX 457

O autorze

RAVIN NARAIN, PhD, is Associate Professor in the Department of Chemical and Materials Engineering at the University of Alberta. He has published more than 100 articles in peer–reviewed journals and is the editor of Engineered Carbohydrate–Based Materials for Biomedical Applications (Wiley). Dr. Narain s research examines nanomedicine and regenerative medicine, with an emphasis on developing new biomaterials for gene delivery and tissue engineering.