Biochemistry of Schizophrenia and Addiction: In Search of a Common Factor

ISBN-13: 9789400987081 / Angielski / Miękka / 2011 / 344 str.

G. Hemmings

Opis

The main theme of this book concems the relationship, if any, between and addietion. Are they linked biochemieally? Is there a schizophrenia common factor for all addietions? We need to know whether the chemis- try of addiction can help clarify the biochemistry of schizophrenia and vice versa. There is much anecdotal evidence that many sufferers from schizophrenia are addieted to smoking, are adversely affected by even small amounts of alcohol and do have their schizophrenie illness wor- sened by street drugs. We would urge our readers to try to find correla- tions between some of the findings described here on the biology of schizophrenia and what they read in the up-to-date chapters on addie- tions. We would like to thank all the authors for the excellence of their work and for their cooperation and understanding of our needs and also, for the second time this year, to thank MTP Press for their willingness to pub- lish a perhaps somewhat provocative book. We thank them for their humanity.

Spis treści

Section 1: Pathogenesis.- 1 The role of a prostaglandin E1 deficiency in schizophrenia: interactions with dopamine and opiates.- 2 The pathogenesis of schizophrenia.- 3 Opiates, opioid peptides and their possible relevance to schizophrenia.- 4 The possible actions of peptides with opioid activity derived from pepsin hydrolysates of wheat gluten and other constituents of gluten in the function of the central nervous system.- 5 Preliminary studies of the identification of brain peptides in relation to the genesis and expression of schizophrenia.- 6 The role of the dopamine system in schizophrenia.- Section 2: Immunology.- 7 The relevance of immunopathology to research into schizophrenia.- 8 Some connections between immunoglobulins and schizophrenia.- 9 Antibodies to wheat proteins in schizophrenia: relationship or coincidence?.- 10 The effects of hormones on immune responses.- 11 Binding of chlorpromazine and HLA-A1 antibodies to human lymphocyte membranes.- 12 The possible role of a prostaglandin Ea deficiency in the immunological abnormalities seen in schizophrenia.- 13 Immunological reaction of psychotic patients to fractions of gluten.- Section 3: Addiction.- 14 ß-endorphin and endoloxone: messengers of the autonomic nervous system for the conservation or expenditure of bodily resources and energy in anticipation of famine or feast.- 15 The pharmacology of tobacco smoking in relation to schizophrenia.- 16 Alcoholism and schizophrenia: a basic science approach.- 17 Opiate dependence and tolerance: a pharmacological analysis.- Section 4: Puerperal Psychoses.- 18 Puerperal schizophrenia?.- Section 5: Enzymology.- 19 The digestion and absorption of dietary protein.- Section 6: Physiology.- 20 Correlation between behavioural responses and cardiovascular changes and the central nervous mechanisms responsible for them.- Section 7: Morbidity and Mortality.- 21 Schizophrenia and physical disease: a preliminary analysis of data from the Oxford Record Linkage Study.- Section 8: Drug Treatments.- 22 Depot neuroleptics and tardive dyskinesia: prospective study.- 23 Recent developments in the drug treatment of schizophrenia.