Bioadhesive Drug Delivery Systems: Fundamentals, Novel Approaches, and Development

ISBN-13: 9780367399603 / Angielski / Miękka / 2019 / 696 str.

Edith Mathiowitz; Donald E. Chickering III; Claus-Michael Lehr

Opis

This invaluable reference presents a comprehensive review of the basic methods for characterizing bioadhesive materials and improving vehicle targeting and uptake-offering possibilities for reformulating existing compounds to create new pharmaceuticals at lower development costs.
Evaluates the unique carrier characteristics of bioadhesive polymers and their power to enhance localization of delivered agents, local bioavailability, and drug absorption and transport!
Written by over 50 international experts and reflecting broad knowledge of both traditional bioadhesive strategies and novel clinical applications, Bioadhesive Drug Delivery Systems

discusses mechanical and chemical bonding, polymer-mucus interactions, the effect of surface energy in bioadhesion, polymer hydration, and mucus rheology

analyzes biochemical properties of mucus and glycoproteins, cell adhesion molecules, and cellular interaction with two- and three-dimensional surfaces

covers microbalances and magnetic force transducers, atomic force microscopy, direct measurements of molecular level adhesions, and methods to measure cell-cell interactions

examines bioadhesive carriers, diffusion or penetration enhancers, and lectin-targeted vehicles

describes vaginal, nasal, buccal, ocular, and transdermal drug delivery

reviews bioadhesive interactions with the mucosal tissues of the eye and mouth, and those in the respiratory, urinary, and gastrointestinal tracts

explores issues of product development, clinical testing, and production

and more!
Amply referenced with over 1400 bibliographic citations, and illustrated with more than 300 drawings, photographs, tables, and display equations, Bioadhesive Drug Delivery Systems serves as a sound basis for innovation in bioadhesive systems and an excellent introduction to the subject. This unique reference is ideal for pharmaceutical scientists and technologist

Spis treści

Fundamentals of Bioadhesion
Definitions, Mechanisms, and Theories of Bioadhesion
Donald E. Chickering III and Edith Mathiowitz
The Role of Water Movement and Polymer Hydration in Mucoadhesion
John D. Smart
A Rheological Approach to Explain the Mucoadhesive Behavior of Polymer Hydrogels
Carla Marcella Caramella, Silvia Rossi, and Maria Cristina Bonferoni
Functional Histology of Epithelia Relevant for Drug Delivery: Respiratory Tract, Digestive Tract, Eye, Skin, and Vagina
Udo Schumacher and Dietlind Schumacher
Biochemical and Functional Aspects of Mucus and Mucin-Type Glycoproteins
Barry James Campbell
Methods of Evaluating Bioadhesive Interactions
Adaptation of a Microbalance to Measure Bioadhesive Properties of Microspheres
Donald E. Chickering III, Camilla A. Santos, and Edith Mathiowitz
Novel Magnetic Technique to Measure Bioadhesion
Benjamin A. Hertzog and Edith Mathiowitz
Principles of Skin Adhesion and Methods for Measuring Adhesion of Transdermal Systems
Michael Horstmann, Walter Müller, and Bodo Asmussen
Force Microscopy of Cells to Measure Bioadhesion
E. zur Mühlen, P. Koschinski, S. Gehring, Robert Ros, Louis Tiefenhauer, Eleonore Haltner, Claus-Michael Lehr, Uwe Hartmann, Falk Schwesinger, and A. Plückthun
Direct Measurement of Molecular-Level Forces and Adhesion in Biological Systems
James Schneider and Matthew Tirrell
A Centrifugation Method for Measurement of Two-Dimensional Binding Characteristics of Receptor-Ligand Interaction
Cheng Zhu, James W. Piper, and Robert A. Swerlick
Novel Concepts and Strategies for Bioadhesive Drug Delivery Systems
Multifunctional Polymers for the Peroral Delivery of Peptide Drugs
Henrik L. Luessen, J. Coos Verhoef, A. (Bert) G. de Boer, H. E. Junginger, Bas J. de Leeuw, Gerrit Borchard, and Claus-Michael Lehr
Chitosan and Chitosan Derivatives as Absorption Enhancers for Peptide Drugs Across Mucosal Epithelia
A. F. Kotzé, Henrik L. Luessen,

O autorze

Edith Mathiowitz, Donald E. Chickerin III, Claus-Michael Lehr