Big on Bk: Current Insights Into the Function of Large Conductance Voltage- And Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Le

ISBN-13: 9780128036198 / Angielski / Twarda / 2016 / 550 str.

Candice Contet

Opis

Big on Bk: Current Insights into the Function of Large Conductance Voltage- and Ca2+- Activated K+ Channels at the Molecular, Cellular and Systemic Levels, a volume in the International Review of Neurobiology series, is a comprehensive overview of the state-of-the-art research into this area. It reviews current knowledge and understanding, and also provides a starting point for researchers and practitioners entering the field.

• The latest volume in the International Review of Neurobiology series
• Provides a broad coverage of subject matter at the molecular, cellular and systemic levels
• Presents an ideal resource for researchers and practitioners, and those just entering the field

Spis treści

1. Biophysics of BK channel gating

  Riccardo Olcese

2. Modulation of BK channel function by auxiliary beta and gamma subunits

  Jiusheng Yan

3. Posttranscriptional and posttranslational regulation of BK channels

  Mike Shipston

4. Protein network interacting with BK channels

  Hongkyun Kim

5. Functional role of mitochondrial and nuclear BK channels

  Tian-Ming Gao

6. Modulation of BK channels by small endogenous molecules and pharmaceutical channel openers

  Toshinori Hoshi

7. Modulation of BK channels by ethanol

  Alex Dopico

8. BK channels in neurons

  Alison Barth

9. BK channels in the pituitary and hypothalamus

  Peter Duncan

10. BK channels in the inner ear

  Sonja Pyott

11. BK channels in the vascular system

  Gayathri Krishnamoorthy-Natarajan

12. Developing the molecular pharmacology of BK channels for therapeutic benefit

  Gregory John Kaczorowski

O autorze

Candice Contet, Ph.D., is Assistant Professor at The Scripps Research Institute (TSRI), La Jolla, CA. She is an NIH-funded investigator with 15 years of experience in the study of drug addiction. She is a member of the Integrative Neuroscience Initiative on Alcoholism (INIA-WEST) consortium funded by NIAAA, and directs the Viral Vector Core of TSRI Alcohol Research Center. She has a documented track record of investigating the molecular changes elicited by drugs of abuse and their relevance to behavioral adaptations. She has authored more than 20 peer-reviewed publications. She is on the editorial board of the journal Frontiers in Molecular Neuroscience. She attended the Ecole Normale Superieure (Paris, France) and obtained her PhD from the University of Strasbourg (France). She completed her research training under the mentoring of Drs. Nick Rawlins, Brigitte Kieffer, Athina Markou and George Koob.