Berries and Cancer Prevention

ISBN-13: 9781441975539 / Angielski / Twarda / 2010 / 313 str.

Gary D. Stoner

Opis

Experimental investigations in the past 10-15 years have provided convincing evidence of the cancer preventive potential of berries. Berries and their components have been shown to reduce the malignant properties of cancer cells in culture by influencing genes associated with cancer development. In addition, diets containing freeze-dried berries have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans.

Spis treści

Berries and Cancer Prevention I. Berry composition, bioavailability, metabolism and biological effects 1. Contribution of berry anthocyanins to their chemopreventive properties - Pu Jing and M. Monica Giusti 2. Ursolic acid and other pentacyclic triterpenoids: Anticancer activities and occurrence in berries - Catherine C. Neto 3. Biological effects of berry extracts on carcinogenic signaling pathways in vitro - Tongjian Cai and Chuanshu Huang II. Antioxidant capacity of berry components 4. Correlation of antioxidants and antioxidant enzymes to oxygen radical scavenging activities in berries - Shiow Y. Wang III. Chemopreventive effects of berries and berry components in animal model systems 5. Berries and the prevention of esophageal adenocarcinoma - Laura A. Kresty, Amy Exum and Bree Zeyzus-Johns 6. Endothelial cell tumor prevention with berry extracts: Clinical problems, molecular mechanisms and therapeutic opportunities - Gayle M. Gordillo, Chandan K. Sen 7. Effects of black raspberries on UV-induced cutaneous inflammation and tumor development - Tatiana M. Oberyszyn 8. Chemopreventive effects of berries and berry components in the rodent esophagus - Claire Seguin, Li-Shu Wang, and Gary Stoner 9. Prevention of estrogen-mediated mammary tumors in ACI rats by berries - Harini Aiyer, Srivani Ravoori and Ramesh Gupta 10. Inhibition of oral cancer in animal models by black raspberries and berry components - Bruce C. Casto, Thomas J. Knobloch and Christopher M. Weghorst 11. Prevention of cancer with pomegranate and pomegranate anthocyanins - Vaqar Mustafa Adhami, Naghma Khan and Hasan Mukhtar 12. Chemoprevention of chronic inflammatory bowel disease-induced carcinogenesis in rodent models by berries - Allison Yang, Haonan Li, WanYing Zhang, Yeon Tae Chung, Jie Liao, and Guang-Yu Yang IV. Use of berries for cancer prevention in high-risk individuals/Berry chemoprevention in high-risk populations/Cancer prevention through berry formulations in high-risk individuals 13. Prevention of oral dysplasia in humans by berry formulations - Susan R. Mallery and Meng Tong 14. Cancer prevention in populations high at-risk for the development of oral cancer: clinical trials with black raspberries - Thomas J. Knobloch, Bruce C. Casto, Amit Agrawal, Steven K. Clinton, and Christopher M. Weghorst 15. Effects of black raspberries on cellular and epigenetic biomarkers of colon cancer development in humans - Gary Stoner, Li-Shu Wang, Christine Sardo, Mark Arnold, Edward Martin, Wendy Frankel, and Dennis Pearl

Blurb

Berries are popularly consumed worldwide as fresh, processed, and other derived forms. Research conducted over the last decade and a half has provided significant and convincing evidence to support the cancer preventive potential of these colorful fruits. Berries and their phytochemical constituents work through multiple mechanisms to reduce the malignant properties of cancer cells in laboratory studies. Further, diets of various berry formulations, including freeze dried berries, have been shown to prevent cancer in animals, and recent data indicate that they also exhibit cancer preventive effects in humans. Providing an unprecedented compilation of current information, this book, Berries and Cancer Prevention: 1) Describes the major groups of bioactive compounds in berries and their antioxidant potential 2) Describes the cancer inhibitory effects of berry extracts and individual components in vitro, and discusses their mechanisms of action on a cellular and molecular level 3) Discusses the cancer-inhibitory effects of berries and berry components on tumor development in animals 4) Discusses recent results on the cancer-inhibitory effects of berries and berry components in humans and describes their mechanisms of action; 5) Discusses the relative merits of the use of whole berries, freeze-dried berries, berry extracts and individual berry components for cancer prevention, particularly in humans. The editors anticipate that this book would be useful for researchers, academicians and trainees associated with departments of nutrition, dietetics, food science and technology, cancer biology, cancer prevention, public health, family medicine, osteopathy, dentistry, etc. It should also be useful for practitioners, dieticians, and others involved in daily patient health care. We also expect that individuals involved in various roles in the berry industry including berry production, product development, marketing and sales, would benefit from this book. The public has a strong interest in healthy foods and dietary interventions for cancer prevention, and we hope that many of those individuals will also find this book of great interest.