Behçet's Disease: A Guide to Its Clinical Understanding Textbook and Atlas

ISBN-13: 9783642630941 / Angielski / Miękka / 2012 / 210 str.

Sungnack Lee; Dongsik Bang; Eun-So Lee

Opis

A Turkish dermatologist named Hulusi Beh et defined a syndrome, the major symptoms of which comprise oral ulcers, genital ulcers, eye lesions, and skin lesions, as a specific disease in 1937, and the disease was named Beh et's disease after him. Since then, there have been more than 4500 reports presented world wide on this disease showing that Beh et's disease is no longer rare. Because Beh et's disease is clinically dynamic and its clinical symptoms are various and their spectrum very wide. However, there are insufficient pathognomic laborato ry data for the diagnosis of Beh et's disease, so it is with great difficulty that Beh et's disease specialists diagnose the disease based only on their clinical expe rience. We have therefore collected data from more than 5500 living Beh et's disease patients whom we have seen, and we have brought together data from other nations and other continents. We hope the result is a clinical guide for those inter ested in Beh et's disease. To improve the accessibility of the information, this text book was made in a photo-monography style with an atlas style, and we have tried our best to make our sentences short and clear. We are grateful to the many scholars worldwide whose contributions have added greatly to the value of this textbook. We are especially grateful to the staff of Springer-Verlag who have shown deep kindness and patience. Special thanks to Ms. Heather Yu for helping us in writing this monograph in English, and Mr. Jung-Woon Lee for his assistance."

Spis treści

I Special Contribution.- Advances in the Immunopathogenesis of Behçet’s Disease.- II Clinical Understanding of Behçet’s Disease.- 1 Introduction.- 1.1 Definition.- 1.2 Synonyms.- 1.3 Other Common Terms.- 1.4 History.- 1.5 Epidemiology.- 2 Etiopathogenesis.- 2.1 Viral Infection.- 2.2 Bacterial Infection.- 2.3 Heat Shock Protein.- 2.4 Environmental Pollution.- 2.5 Autoimmune Theory.- 2.6 Immunogenetics.- 2.6.1 Familial Occurrence.- 2.6.2 Immunogenetic Aspect.- 3 Clinical Manifestations.- 3.1 Major and Minor Symptoms.- 3.1.1 Occurrence.- 3.1.2 Initial Manifestations.- 3.2 Oral Ulcers.- 3.2.1 Clinical Manifestations.- 3.2.2 Clinical Course of Oral Ulcers.- 3.2.3 Experimentally Induced Oral Ulcers.- 3.2.4 Sequelae from Recurrent Episodes of Oral Ulcers.- 3.2.5 Pediatric Oral Ulcers.- 3.2.6 Prognosis of Recurrent Oral Ulcers.- 3.3 Genital Ulcers.- 3.3.1 Clinical Features.- 3.3.2 Clinical Course of Genital Ulcers.- 3.3.3 Other Urogenital Features.- 3.4 Cutaneous Manifestations.- 3.4.1 Clinical Features.- 3.5 Ocular Manifestations.- 3.5.1 Clinical Features.- 3.5.2 Clinical Course.- 3.5.3 Pediatric Ocular Manifestations.- 3.5.4 Prognosis.- 3.6 Joint Manifestations.- 3.6.1 Clinical Features.- 3.6.2 Clinical Course.- 3.6.3 Joint Involvement in Pediatric Patients.- 3.6.4 Operative Findings.- 3.7 Gastrointestinal Involvement.- 3.8 Vascular Manifestations.- 3.9 Neurologic and Psychiatric Manifestations.- 3.9.1 Clinical Features.- 3.9.2 Clinical Progress.- 3.10 Other Organ Manifestations.- 3.11 Pregnancy-Associated Manifestations.- 4 Diagnosis.- 4.1 Diagnostic Criteria.- 4.2 Pathergy (Skin Hyperreactivity).- 4.3 Laboratory Findings.- 4.4 Differential Diagnosis.- 5 Immunologic Aspects.- 5.1 Cell-Mediated Immunity.- 5.1.1 DNCB Responsiveness.- 5.1.2 T and B Cells.- 5.1.3 Antibody-Dependent Cellular Cytotoxicity (ADCC) and Natural Killer (NK) Cells.- 5.1.4 Cytokines.- 5.2 Humoral Immunity.- 5.2.1 Serum Immunoglobulins.- 5.2.2 Circulating Immune Complexes.- 5.2.3 Autoantibodies.- 6 Histopathology.- 6.1 Characteristics.- 6.2 Light Microscopic Findings.- 6.3 Electron Microscopic Findings.- 7 Interdepartmental Cooperation Approach System.- 8 Therapy.- 9 Prognosis.- 10 Prevention.- 11 Animal Models.- 11.1 Environmental Pollution.- 11.2 HLA-B51.- 11.3 Heat Shock Protein.- 11.4 Herpes Simplex Virus Infection.- Appendix Special issue on Behçet’s Disease of Yonsei Medical Journal (Vol 38, No. 6, December 1997).- Appendix 1 Life Story of Dr. Hûlusi Behçet.- Appendix 2 Molecular Genetics (HLA) of Behçet’s Disease.- Appendix 3 Behçet’s Disease Etiopathology: Immunological Aspects*.- Appendix 4 Etiopathology of Behçet’s Disease: Herpes Simplex Virus Infection and Animal Model.- Appendix 5 Diagnostic Criteria of Behçet’s Diesease: Problems and Suggestions.- Appendix 6 Recurrent Aphthous Stomatitis in the Diagnosis of Behçet’s Disease*.- Appendix 7 Dermatologic Manifestation of Behçet’s Disease.- Appendix 8 Ophthalmologic Manifestations of Behçet’s Disease.- Appendix 9 Behçet’s Disease — A Rheumatologic Perspective.- Appendix 10 Treatment of Behçet’s Disease.- Appendix 11 Adamantiades-Behçet’s Disease: Epidemiology in Germany and in Europe*.- Appendix 12 Clinical Manifestations of Behçet’s Disease: An Analysis of 2147 Patients*.- Appendix 13 Epidemiological and Clinical Features of Behçet’s Disease in Korea.- Appendix 14 The Influence of Pregnancy on Behçet’s Disease.- Appendix 15 Immunological Aspects of Hyperreactivity to Streptococcal Antigens in Behçet’s Disease*.- Appendix 16 Surgical Treatment of Intestinal Behçet’s Disease.