Behavioral Neurogenetics

ISBN-13: 9783642278587 / Angielski / Twarda / 2012 / 636 str.

John F. Cryan; Andreas Reif

Opis

This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.

Spis treści

Preface.- Introduction to Behavioral Neurogenetic.- Part I. Preclinical Behavioral Genetics.- Using Non-Mammalian Model Organisms to unravel the genetics of complex disorders. Forward genetic approaches to understanding complex behaviors. Animal models of gene x environment risk factors for mental illness. Pharmacogenetic studies of aggressive behavior. Selectively bred models of anxiety and depression. Genetic approaches to understand fear and anxiety. Susceptibility genes for schizophrenia: endophenotypes and mutant models. Genetic models of sensorimotor gating.- Part II. Clinical Behavioural Genetics.- Applications of next generation sequencing technologies in complex disorders. Rare genomic deletions and duplications and their role in neurodevelopmental disorders. Neuroimaging at the interface of genes, brain, and behavior. Behavioral genetics on childhood disorders. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Gene x environment interaction models in psychiatric genetics. Behavioral genetics of affective and anxiety disorders.  Molecular genetics of human monoaminergic transporters: relevance to behavioural disorders and drug response. Genetic variation in responses to stimulant drugs. The cognitive genetics of neuropsychiatric disorders. Behavioral genetics of neurodegenerative disorders.

Blurb

The field of behavioral neurogenetics has developed significantly over the past two decades. This has been largely driven by technical advances in the field of molecular genetics both in model systems and in clinical analysis. Indeed, it is hoped that the elucidation and ongoing functionalisation of the human genome may provide new insights into the aetiology, course and, ultimately, treatment of psychiatric illnesses. This book covers a wide array of topics relevant to behavioral genetics from both a preclinical and clinical standpoint. Indeed in juxtaposing both areas of research the reader will appreciate the true translational nature of the field. Topics covered range from technical advances in genetic analysis in humans and animals to specific descriptions of advances in schizophrenia, attention disorders, depression and anxiety disorders, autism, aggression, neurodegeneration and neurodevelopmental disorders. The importance of gene-environment interactions is emphasised and the role of neuroimaging in unravelling the functional consequences of genetic variability described. This volume will be valued by both the basic scientist and clinician alike who may use it as a detailed reference book. It will also be of use to the novice to the field, to whom it will serve as an in-depth introduction to this exciting area of research.