Behavioral Neurobiology of Anxiety and Its Treatment

ISBN-13: 9783642029110 / Angielski / Twarda / 2010 / 350 str.

Murray B. Stein

Opis

The book is part of a series on Current Topics in Behavioral Neurosciences, which has as its focus anxiety and its treatment. We have brought together a distinguished cadre of authors with the aim of covering a broad array of topics related to anxiety disorders, ranging from clinical diagnosis, epidemiology, preclinical neuroscience, and animal models to established and innovative therapeutic approaches. The book aims at bridging these disciplines to provide an update of literature relevant to understanding anxiety, its consequences, and its management. Following is a brief overview of the chapters and their content, meant to serve as a guide to navigating the book. The ?rst section covers clinical aspects of anxiety disorders. Joe Bienvenu and colleagues provide an incisive overview of diagnostic considerations in the anxiety disorders in which they emphasize the strengths and shortcomings of our current nosologic systems. This is followed by a review and update of the epidemiology of anxiety disorders by Ron Kessler and colleagues, which provides an authoritative survey of anxiety disorder incidence, prevalence, and risk factors. This is comp- mented by a comprehensive review of the literature on disorders that co-occur with anxiety disorders by Kathleen Merikangas and Sonja Alsemgeest Swanson. Their review highlights the tremendous comorbidity that occurs not only within the anxiety disorders, but also with other mental and physical health conditions.

Spis treści

Anxiety Disorders Diagnosis: Some History and Controversies.- Epidemiology of Anxiety Disorders.- Comorbidity in Anxiety Disorders.- Genetics.- Neuroanatomy of Anxiety.- Stress and the Neuroendocrinology of Anxiety Disorders.- Animal Models of Anxiety and Anxiolytic Drug Action.- Genetic Approaches to Modeling Anxiety in Animals.- Behavioral Correlates of Anxiety.- Challenging Anxiety: A Focus on the Specificity of Respiratory Symptoms.- Functional Neuroanatomy of Anxiety: A Neural Circuit Perspective.- Pharmacological Enhancement of Behavioral Therapy: Focus on Posttraumatic Stress Disorder.- The Pharmacology of Anxiety.- GABAA Receptor ?2/?3 Subtype-Selective Modulators as Potential Nonsedating Anxiolytics.- Antidepressant Treatment in Anxiety Disorders.- Metabotropic Glutamate Receptors: Their Therapeutic Potential in Anxiety.- Developing Small Molecule Nonpeptidergic Drugs for the Treatment of Anxiety Disorders: Is the Challenge Still Ahead?.- Cannabinoids and Anxiety.- Pharmacological Treatment of Generalized Anxiety Disorder.- Pharmacologic Treatment of Panic Disorder.- Pharmacotherapy of Social Anxiety Disorder.- Pharmacotherapy of Post-Traumatic Stress Disorder.- Pharmacological Treatment of Obsessive-Compulsive Disorder.

O autorze

Murray B. Stein, MD, MPH, FRCPC, is Professor of Psychiatry and Family Preventive Medicine at the University of California, San Diego (UCSD) and Director of the Anxiety Traumatic Stress Program at UCSD and at the Department of Veterans Affairs San Diego Healthcare System. He graduated from the University of Manitoba and was a postgraduate trainee at the University of Toronto and at the National Institute of Mental Health in Bethesda, Maryland, USA. He subsequently completed a Master of Public Health degree at the Johns Hopkins University Bloomberg School of Public Health. His research interests include the neurobiology, epidemiology, and treatment of anxiety disorders including social phobia, panic disorder, and posttraumatic stress disorder. His federally funded research includes studies of interventions for anxiety disorders in primary care, pharmacological approaches to treatment-resistant anxiety disorders, and functional neuroimaging research in anxiety and trauma-related disorders. Dr. Stein is a member of the Scientific Advisory Board of the Anxiety Disorders Association of America (ADAA), Scientific Chair of the NIH Interventions in Mood and Anxiety (ITMA) Review Group, a reviewer for numerous journals, and a member of the editorial boards of Depression & Anxiety, General Hospital Psychiatry, The Science World (TSW) Psychiatry, and Trends in Evidence-Based Neuropsychiatry.