Bayesian Biostatistics and Diagnostic Medicine

ISBN-13: 9781584887676 / Angielski / Twarda / 2007 / 216 str.

Lyle D. Broemeling

Opis

There are numerous advantages to using Bayesian methods in diagnostic medicine, which is why they are employed more and more today in clinical studies. Exploring Bayesian statistics at an introductory level, Bayesian Biostatistics and Diagnostic Medicine illustrates how to apply these methods to solve important problems in medicine and biology.
After focusing on the wide range of areas where diagnostic medicine is used, the book introduces Bayesian statistics and the estimation of accuracy by sensitivity, specificity, and positive and negative predictive values for ordinal and continuous diagnostic measurements. The author then discusses patient covariate information and the statistical methods for estimating the agreement among observers. The book also explains the protocol review process for cancer clinical trials, how tumor responses are categorized, how to use WHO and RECIST criteria, and how Bayesian sequential methods are employed to monitor trials and estimate sample sizes.
With many tables and figures, this book enables readers to conduct a Bayesian analysis for a large variety of interesting and practical biomedical problems.

Spis treści

INTRODUCTIONIntroductionStatistical Methods in Diagnostic MedicinePreview of BookDatasets for BookSoftwareReferencesDIAGNOSTIC MEDICINEIntroductionImaging ModalitiesActivities in Diagnostic MedicineAccuracy and AgreementDevelopmental Trials for ImagingProtocol Review and Clinical TrialsThe LiteratureReferences OTHER DIAGNOSTIC PROCEDURESIntroductionSentinel Lymph Node Biopsy for MelanomaTumor Depth for Diagnosis of Metastatic MelanomaA Biopsy of Non-Small Cell Lung CancerCoronary Artery DiseaseBAYESIAN STATISTICSIntroductionBayes TheoremPrior InformationPosterior InformationInferenceSample SizeComputingExercisesReferencesBAYESIAN METHODS FOR DIAGNOSTIC ACCURACYIntroductionStudy DesignBayesian Methods for Diagnostic Accuracy: Binary and Ordinal DataBayesian Methods for Test Accuracy: Quantitative VariablesClustered DataComparing Accuracy between ModalitiesSample Size DeterminationExercisesReferencesREGRESSION AND TEST ACCURACYIntroductionThe Audiology StudyThe ROC Curve and Patient CovariatesExercisesReferencesAGREEMENTIntroductionAgreement for Discrete RatingsAgreement for a Continuous ResponseCombining Reader InformationExercisesReferencesDIAGNOSTIC IMAGING AND CLINICAL TRIALSIntroductionClinical TrialsThe ProtocolGuidelines for Tumor ResponseBayesian Sequential Stopping RulesSoftware for Clinical TrialsExamplesExercisesReferencesOTHER TOPICSIntroductionImperfect Diagnostic Test ProceduresTest Accuracy and Survival AnalysisROC Curves with a Non-Binary Gold StandardPeriodic Screening in CancerDecision Theory and Diagnostic AccuracyExercisesReferences

O autorze

Lyle D. Broemeling