Basic and Translational Applications of the Network Theory for Dystonia

ISBN-13: 9783031262197 / Angielski

Aasef Shaikh; Anna Sadnicka

Opis

A recently proposed novel scheme of dystonia suggests that it is a disorder of neural network.  Impairment in any of the “nodes” of the network may result in deficient network activity, causing dystonia.  This book aims to present various experimental evidence supporting the network theory of dystonia.  Dystonia is the abnormal twisting and turning of the organ and associated involuntary oscillations.  Although dystonia is less common than Parkinson’s disease, traumatic brain injury, or stroke, each of these common disorders present with dystonia.  Information regarding the brain regions that may be involved in dystonia is surprisingly limited and often conflicting.    With chapters written by subject matter experts, this is a unique title that focuses on dystonia as a network disorder.  This book would be of interest to basic and clinical researchers with an interest in motor systems and movement disorders.

Spis treści

Editorial

Dystonia in childhood - how insights from paediatric research enrich the network theory of dystonia

Focal Dystonia and the Stress-Network

Limbic influences in Musicians dystonia

Network perspective on task-specific dystonia

Electromyography as a method for distinguising dystonia-like behavior in mice

Deep brain stimulation of the interposed cerebellar nuclei in a mouse model of dystonia

Applications of Transcranial Magnetic Stimulation for understanding and treating dystonia

Brain connectivity in dystonia: evidence from Magnetoencephalography

Dysfunctional networks in functional dystonia

Collicular-pulvinar-amygdala axis and adult-onset idiopathic focal dystonia syndrome  

Neuromodulation in dystonia

Electrophysiological properties of pallidal cells in cervical dystonia patients undergoing unilateral DBS

Clinical implications of dystonia as a neural network disorder

O autorze

Aasef G Shaikh, MD,PhD is a Penni and Stephen Weinberg Chair in Brain Health at University Hospitals Cleveland. He is a Professor and Vice-Chair for research in Neurology at Case Western Reserve University. Dr Shaikh directs National VA Parkinson Consortium Center at Cleveland VA and is a principal investigator in Daroff DellOsso Oculomotor Laboratory. His interdisciplinary research focuses on motor systems, eye movement and vestibular control. The overarching goal of his research program is to study mechanistic underpinning of complex neurological disorders affecting the eye and head movements and vestibular function.

Dr Anna Sadnicka BSc MBChB MRCP PhD

Anna is a Clinical Lecturer fascinated by the neural control of movement and how this is disturbed in movement disorders.  Her award-winning research combines behavioural experiments, electrophysiology, and computational models to shed light on dystonia mechanism.  She has a particular emphasis on translating her research into novel movement retraining and neuromodulation strategies.