Basic and Clinical Research on Renal Cell Carcinoma

ISBN-13: 9783642768651 / Angielski / Miękka / 2011 / 237 str.

Gerd Staehler; Sigmund Pomer

Opis

Advanced Renal Cell Carcinoma (RCC) cannot be cured by surgery alone. Its resillience to irradiation and chemotherapy demands a new approach to the management of this disease. This book provides an overview of the scientific and clinical developments of RCC, and clarifies the fields ofimmunotherapy and immunobiology. The book contains a compilation of approaches that will enhance the effectiveness of the management of advancedRCC, even in the absence of definitive pre-clinical data. These require additional study and will stimulate the reassessment of preliminary results.Furthermore, preliminary results of already implemented clinical trials withbiological modifiers are presented. Of special interest are the current achievements in the field of immunotherapy using topically and subcutaneously low dosage combinations of cytokines. This concise volume will benefit those seeking a thorough review of the research and the clinical aspects of RCC simultaneously.

Spis treści

Molecular and Cellular Basis of Renal Cell Carcinoma.- Molecular Differential Pathology of Renal Cell Tumors.- Pathobiology of Renal Carcinogenesis.- Molecular Analysis of DNA Sequences on Chromosome 3 in Patients with Renal Cell Carcinoma.- Cell Proliferation and Cellular Heterogeneity in Renal Cell Carcinoma.- 31P NMR Spectroscopy of Human Tumor Cells In Vitro and In Vivo: Prospects for Applications to Renal Cell Carcinoma.- Conservative Surgery of Renal Tumors: Operative Technique, Complications, Results, DNA Cytometry.- Clinical Relevance of Proliferation Rates in Renal Cell Carcinoma.- Chemotherapy of Renal Cell Carcinoma.- Cytotoxic Chemotherapy Phase II Trials Between 1983 and 1990 for Advanced Renal Cell Carcinoma.- Modulation of Multidrug Resistance in Human Renal Cell Carcinomas.- Transgenic Mice Carrying the Human MdR 1 Gene: Reliable In Vivo Probes to Examine Multidrug Resistance.- Adhesion Molecules and Their Possible Influence on Immune Surveillance.- Immunobiology of Renal Cell Carcinoma.- Anti-Proliferative and Anti-Tumor Effect of a-Interferon in Renal Cell Carcinoma: Correlation with the Expression of a Kidney Associated Differentiation Glycoprotein.- Prediction of Cytokine-Therapy on Basis of Class-I and Class-II MHC Antigen Induction.- Alien Gene Transfection and the Immune Response to Tumors.- Active Specific Immunotherapy with Tumor Cells Expressing a Foreign Gene.- Novel Monoclonal Antibody 138H11 Against Human ?-Glutamyl-Transferase: Classification, Histogenesis and Immunoscintigraphy of Renal Tumors.- T-Cell Activation by Bispecific Monoclonal Antibodies for Lysis of Renal Cell Carcinoma In Vitro.- Immunotherapy of Renal Cell Carcinoma.- New Experimental Approaches to the Adoptive Immunotherapy of Cancer: Cytokines, Gene Therapy, Oncogenes and Transgenic Mice.- Cytokines as Possible Adjuvants to Vaccines in Active Specific Immunotherapy for Renal Cell Carcinoma.- Tumor Infiltrating Lymphocytes in Renal Cell Cancer.- Combined Vaccination with Autologous Tumor Material and Subcutaneously Administered rIL-2 and rIFN-?-2b in the Treatment of Renal Cell Carcinoma.- Interleukin-2 by Inhalation: Local Therapy for Metastatic Renal Cell Carcinoma.