Basic Neurochemistry: Principles of Molecular, Cellular and Medical Neurobiology

ISBN-13: 9780123749475 / Angielski / Twarda / 2011 / 1096 str.

George Siegel; R. Wayne Albers

Opis

Basic Neurochemistry, Eighth Edition, is the updated version of the outstanding and comprehensive classic text on neurochemistry. For more than forty years, this text has been the worldwide standard for information on the biochemistry of the nervous system, serving as a resource for postgraduate trainees and teachers in neurology, psychiatry, and basic neuroscience, as well as for medical, graduate, and postgraduate students and instructors in the neurosciences. The text has evolved, as intended, with the science. This new edition continues to cover the basics of neurochemistry as in the earlier editions, along with expanded and additional coverage of new research from intracellular trafficking, stem cells, adult neurogenesis, regeneration, and lipid messengers. It contains expanded coverage of all major neurodegenerative and psychiatric disorders, including the neurochemistry of addiction, pain, and hearing and balance; the neurobiology of learning and memory; sleep; myelin structure, development, and disease; autism; and neuroimmunology.

• Completely updated text with new authors and material, and many entirely new chapters
• Over 400 fully revised figures in splendid color
• 61 chapters covering the range of cellular, molecular and medical neuroscience
• Translational science boxes emphasizing the connections between basic and clinical neuroscience
• Companion website at http: //elsevierdirect.com/companions/9780123749475

Spis treści

Part I: Cellular Neurochemistry and Neural Membranes Cell Biology of the Nervous SystemCell Membrane Structures and FunctionsMembrane TransportElectrical Excitability and Ion Channels Lipids The Cytoskeleton of Neurons and Glia Intracellular Trafficking Axonal Transport Cell Adhesion Molecules Myelin Structure and Biochemistry Energy Metabolism of the Brain

PART II: Intercellular Signaling Synaptic Transmission and Cellular Signaling: An Overview Acetylcholine Catecholamines Serotonin Histamine Glutamate and Glutamate ReceptorsGABA Purinergic Signaling Peptides

PART III: Intracellular SignalingG Proteins Cyclic Nucleotides in the Nervous System Phosphoinositides Calcium Serine and Threonine Phosphorylation Tyrosine Phosphorylation Transcription Factors in the Central Nervous System

PART IV: Growth, Development and Differentiation Development of the Nervous SystemGrowth Factors Stem Cells in the Nervous System Formation and Maintenance of MyelinAxonal Growth in the Adult Mammalian Nervous System

PART V: Cell Injury and Inflammation Molecular Mechanisms and Consequences of Immune and Nervous System ReactionsNeuroinflammationBrain Ischemia and Reperfusion: Cellular and Molecular Mechanisms in Stroke InjuryLipid Mediators: Eicosanoids, Docosanoids and Platelet-Activating Factor Apoptosis and Necrosis

PART VI: Inherited and Neurodegenerative Diseases Peripheral Neuropathy Diseases Involving Myelin The Epilepsies: Phenotypes and Mechanisms Genetics of Neurodegenerative Diseases Disorders of Amino Acid Metabolism Inborn Metabolic Defects of Lysosomes, Peroxisomes, Carbohydrates, and Fatty Acids and MitochondriaDisorders of Muscle Excitability Motor Neuron Diseases Neurobiology of Alzheimer's Disease Synucleinopathies and Tauopathies Cellular and Molecular Basis of Neurodegeneration in the CAG-Polyglutamine Repeat DiseasesNeurotransmitters and Disorders of the Basal Ganglia Molecular Basis of Prion Diseases

PART VII: Sensory Transduction Molecular Biology of Vision Molecular Biology of Olfaction and Taste Molecular Biology of Hearing and Balance Pain

PART VIII: Neural Processing and Behavior Endocrine Effects on the Brain and Their Relationship to Behavior Learning and Memory The Neurochemistry of Sleep and WakefulnessThe Neurochemistry of Schizophrenia The Neurochemistry of AutismNeurobiology of Severe Mood and Anxiety Disorders Addiction

O autorze

OBITUARY FOR R. WAYNE ALBERS, August 5, 1928 - September 28, 2013

R. Wayne Albers, Ph.D., Scientist Emeritus, Chief of Section on Enzyme Chemistry (retired), Laboratory of Neurochemistry in the NINDS, NIH, Bethesda, MD, is a world-recognized neuroscientist most noted for his research in the field of membrane cation transport and neuronal excitability in the nervous system. Dr. Albers and physiologist R.L. Post performed the principal experiments leading to their now widely-held Albers-Post model for the mechanism of the cation transport enzyme, sodium-potassium-activated ATPase. Dr. Albers was one of the founding co-editors of the comprehensive text, Basic Neurochemistry: Molecular, Cellular and Medical Aspects, first published in 1972, continuing as co-editor for 8 editions, the latest having been published in 2012. After receiving his PhD at Washington University School of Medicine in 1954, Dr. Albers embarked on a distinguished career of research at the NIH, being a founding investigator in the first Laboratory of Neurochemistry.

Dr. Albers was one of the first members of the American Society for Neurochemistry at its inception, serving on its Council and its Committees on Publications and Education and on Electronic Publications. He has served as Professor of Biochemistry at George Washington University, Faculty Member of the NIH Foundation for Advanced Education in the Sciences, Associate Editor of the Journal of Neurochemistry and of Experimental Neurology, and on the editorial boards of several journals.

Dr. Albers passed away on September 28, 2013. He was 85 years old and is survived by his former wife, Frances Albers, their children Gail Morrell, Belinda Caron and Patricia Steinhoff, 6 grandchildren, and 8 great-grandchildren. He also had a son, the late Jonathan Albers.

Dr. Albers was considered a gentleman, an excellent scientific colleague with a keen intellect and friend by all who worked with him. He will be sorely missed, not only by his family, but also by the entire neurochemistry community.

George J. Siegel

October 1, 2013