Basic Aspects of Catechol-O-Methyltransferase and the Clinical Applications of Its Inhibitors: Volume 95

ISBN-13: 9780123813268 / Angielski / Twarda / 2010 / 336 str.

Alireza Minagar

Opis

Volume 95 of International Review of Neurobiology focuses on Catechol-O-methyltransferase inhibition, and its clinical application in relation to Parkinson's disease. Chapters cover COMT gene and proteins, L-dopa treatment in Parkinson's disease, the latest research on COMT inhibitors and their clinical applications, as well as future prospects for their use.

• Up-to-date summary of biochemistry and pharmacology of COMT and its inhibitors
• Preclinical models in COMT inhibitor devlopment
• Transgenic COMT mice - latest information summarized
• Chemistry of COMT inhibitors and their design with molecular modelling
• COMT gene and its regulation and relation to dopamine related diseases
• Role of cofactor SAM regulation in relation to homocysteine
• Nonclinical and clinical safety of COMT inhibitors summarized
• Future prospects of COMT inhibitors in Parkinson's disease

Spis treści

1. Introductory remarks: Catechol-O-methyltransferase inhibition: an innovative approach to enhance L-dopa therapy in Parkinson's disease with dual enzyme inhibition

Erkki Nissinen

2. The catechol-O-methyltransferase gene, its regulation and polymorphisms

Elizabeth M. Tunbridge

3. Distribution and functions of catechol-O-methyltransferase proteins: do recent findings change the picture?

Timo T. Myöhänen & Pekka T. Männistö

4. Catechol-O-methyltransferase enzyme: Cofactor S-adenosyl-L-methionine and related mechanisms

Thomas Müller

5. Biochemistry and pharmacology of catechol-O-methyltrasferase inhibitors

Erkki Nissinen and Pekka T. Männistö

6. The Chemistry of Catechol-O-methyltransferase Inhibitors

David A. Learmonth, László E. Kiss and Patrício Soares-da-Silva

7. Toxicology and safety of COMT inhibitors

Kristiina Haasio

8. Catechol-O-methyltransferase inhibitors in preclinical models as adjuncts of the L-dopa treatment

Concepció Marin, J.A. Obeso

9. Problems with the present inhibitors and a relevance of new and improved COMT inhibitors in Parkinson's disease

Seppo Kaakkola

10. Catechol-O-methyltransferase and pain

Oleg Kambur & Pekka T. Männistö