Bacterial Resistance to Antimicrobials

ISBN-13: 9780849391903 / Angielski / Twarda / 2007 / 444 str.

Wax G. Wax; Richard G. Wax; Richard G. Wax

Opis

Focusing on combating bacterial pathogens by understanding their strategies of defense, this book highlights the antibiotic resistance in pathogens that poses the greatest threat to human health. Each chapter begins with a summary of concepts, so those not actively working in the field gain an overall picture of what follows. Containing nearly 2000 references for additional research, the book presents the molecular basis, methods of detection and identification, and concepts for reducing the development and spread of resistant bacterial strains. It has been called "a useful reference book," and "a comprehensive and straightforward guide" by The Bulletin of the Royal College of Pathologies.

Spis treści

Microbial Drug Resistance: A Historical Perspective. Ecology of Antibiotic Resistance Genes. Global Response Systems that Confer Resistance. Multidrug Efflux Pumps: Structure, Efflux, and Inhibition. Mechanisms of Aminoglycoside Antibiotic Resistance. Resistance to ß-Lactam Antibiotics Mediated by ß-Lactamases. Target Modification as a Mechanism of Antimicrobial Resistance. Antibiotic Permeability. Genetic Methods for Detecting Bacterial Resistance Genes. The Evolution and Epidemiology of Antibiotic Resistant Pneumococci. Antimicrobial Resistance in the Enterococcus. Methicillin Resistance in Staphylococcus aureus. Mechanism of Drug Resistance in Mycobacterium tuberculosis. Antibiotic Resistance in Enterobacteria. Resistance as a Worldwide Problem. Public Health Responses to Antimicrobial Resistance in Outpatient and Inpatient Settings. Antibacterial Drug Discovery in the 21st Century.

O autorze

Richard G. Wax, Kim Lewis, Abigail A. Salyers, Harry Taber