Baciullus cereus haemolysin II: illusion or reality?

ISBN-13: 9786203544190 / Angielski / Miękka / 148 str.

Janna Budarina

Opis

Bacterial toxins are rightly regarded as essential pathogenicity factors in the bacteria that produce them. Hence the traditional sustained interest in the study of these substances. Bacillus cereus, the closest relative of the anthrax pathogen, B. antracis, produces a wide range of toxins. However, their range is far from being fully understood. Thus, one of the hemolytic toxins of B. cereus, hemolysin II, eluded researchers for decades. The existence of this hemolysin was disputed, its activity attributed to other proteins. Clarity in this matter was achieved when a new gene hlyII was cloned from the B. cereus genome, the protein product of which was identified as haemolysin II. On the basis of amino acid sequence analysis, haemolysin II belongs to the family of beta-folded pore-forming oligomeric cytolysins. The expression of hlyII is controlled by the protein product of the first described gene hlyIIR, which is capable of acting as both a positive and negative regulator of hlyII. The ability to produce haemolysin II is a strain-specific property of B. cereus and B. thuringiensis.

O autorze

Budarina, JannaZhanna Igorevna Budarina, PhD in biology, defended her thesis in genetics at the State Research Institute of Genetics in Moscow and is a researcher at the Laboratory of Molecular Microbiology at the Skryabin Institute of Biochemistry of the Russian Academy of Sciences. Scientific work is related to the study of mechanisms of regulation of bacterial toxin genes.