B Cells in Immunity and Tolerance

ISBN-13: 9789811535314 / Angielski / Twarda / 2020 / 181 str.

Ji-Yang Wang

Spis treści

B cell development and maturation.- B cell receptor signalling.- Involvement of reactive oxygen species (ROS) in BCR signaling as a second messenger.- Germinal center reaction.- Memory B cells in local and systemic sites.- Regulation of plasma cell differentiation.- Regulation of humoral immune responses and B cell tolerance by the IgM Fc receptor.- Regulatory B cells.- Diversified IgA-bacteria interaction in gut homeostasis.- Primary antibody deficiencies.- B cell-mediated autoimmune diseases.- B cell lymphomas.

O autorze

Dr. Ji-Yang Wang is a professor at Department of Immunology, School of Basic Medical Sciences, Fudan University, China. He was recruited to the 1000Talents Program of Shanghai in 2013. Prof. Wang’s research focuses on B cell development, activation and differentiation, and B cell-related diseases. He has published more than 100 articles on international journals in these fields.

Blurb

This book contains twelve chapters contributed by prestigious international experts who are at the forefront of B cell research, and aims to provide a cutting-edge and comprehensive overview of all aspects of B cells, including B cell development, maturation and activation, germinal center reaction, memory and plasma cell differentiation, and antibody-mediated positive and negative regulation of humoral immune responses. There are also three chapters describing human diseases caused by B cell abnormalities, including primary antibody deficiencies, autoimmune diseases, and B cell malignancies. We hope that this book will become a standard and routine reference for both basic researchers and clinicians.