1. The importance of the avian immune system and its unique features 2. Structure of the avian lymphoid system 3. Development of the avian hematopoietic and immune systems 4. B cells, the bursa of Fabricius, and the generation of antibody repertoires 5. Structure and evolution of avian immunoglobulins 6. Avian T cells: Antigen Recognition and Lineages 7. The avian major histocompatibility complex 8. Introduction to the avian innate immune system; properties, effects, and integration with other parts of the immune system 9. Avian cytokines and their receptors 10. Immunogenetics and the mapping of immunological functions 11. The mucosal immune system 12. Impact of the gut microbiota on the immune system 13. Innate defenses of the avian egg 14. Avian immunosuppressive diseases and immune evasion 15. Factors modulating the avian immune system 16. Autoimmune diseases of poultry 17. Tumors of the avian immune system 18. Practical aspects of poultry vaccination 19. Comparative immunology of agricultural birds 20. Evolutionary and ecological immunology 21. Advances in genetic engineering of the avian genome