Autoimmune Thyroiditis: Approaches Towards Its Etiological Differentiation

ISBN-13: 9783540534761 / Angielski / Miękka / 1991 / 308 str.

Werner A. Scherbaum; Ulrich Bogner; Balthasar Weinheimer

Opis

Based on a workshop, this text provides a summary of the current knowledge relevant to the understanding of thyroid autoimmunity. Leading scientists review data from four areas: immunogenetics, thyroid peroxidase as an antigen, environmental factors and cytokines.

Spis treści

Immunogenetics.- New Insights into Autoimmune Mechanisms and the Pathogenesis of Insulin-Dependent Diabetes Mellitus.- Discussion.- Thyroid Antibodies and Thyroid Dysfunction in Patients with Type 1 Diabetes and Their First-Degree Relatives.- Discussion.- Association of HLA Class I and Class II Genes and Adrenal Steroid 21-Hydroxylase Gene with Subacute (de Quervain’s) and Hashimoto’s Thyroiditis: Evidence for an Altered Negative Feedback in Hashimoto’s Thyroiditis.- Discussion.- Strongest Relative Risk for Goitrous Hashimoto’s Thyroiditis Conferred by HLA-DQB1 Gene Variation.- Discussion.- A Search for Linkage Between Phenylthiocarbamide Tasting, the Kell Blood Group Locus and Autoantibodies to Thyroglobulin and Thyroid Peroxidase.- Discussion.- Autoimmune Thyroiditis: Its Implications with Other Organ Systems.- Discussion.- The Genetic Control of Thyroid Cell MHC Class II Antigen Expression.- Discussion.- Thyroid Peroxidase. Approaches Towards its Characterization.- Clinical Applications of Thyroid Peroxidase Autoantibody Determination.- Discussion.- Comparison Between Microsomal Antibodies by Immunofluorescence and Anti-TPO Antibodies in Healthy Individuals and Thyroid Autoimmune Disease.- Discussion.- Longitudinal and Cross-Sectional Studies on Anti-Thyroid Peroxidase Antibodies in Thyroid Disorders Compared to Conventional Anti-Microsomal Antibodies.- Discussion.- Comparison of New and Conventional Assay Techniques for Measuring Thyroid Microsomal Antibodies.- Discussion.- Further Clarification of the Significance of Thyroid Peroxidase Activity-Inhibiting Immunoglobulins in Autoimmune Thyroid Disease.- Discussion.- Biochemical Dissection of the Reactivity of TPO Antibodies.- Discussion.- T Cell Epitopes and Thyroid Peroxidase.- Discussion.- Thyroid Microsome/Thyroid Peroxidase Autoantigenic Epitopes Recognized by Autoantibodies Map to the Amino Terminal, the Central Core and the Carboxyl Terminal of the Molecule.- Discussion.- Comparison of Circulating Thyroid Microsomal, Cytotoxic and Thyroid Peroxidase Antibodies.- Discussion.- Are TPO Antibodies and Cytotoxic Thyroid Antibodies Identical?.- Discussion.- Studies with Recombinant Autoepitopes of Thyroid Peroxidase.- Discussion.- Environmental Effects on the Development of Autoimmune Thyroiditis.- Mechanisms by Which Iodine Induces Autoimmunity.- Discussion.- Goiter and Autoimmune Thyroiditis in Iodine-Sufficient Areas.- Discussion.- Prevalence of Postpartum Thyroiditis in two Iodine-Deficient Regions of Germany.- Discussion.- An Immunosuppressive Factor Sharing Homology with P15E Protein of Leukomogenic Retroviruses is Present in the Serum of Patients with Graves’ Disease.- Discussion.- Hashimoto’s Thyroiditis and Enteropathogenic Yersinia enterocolitica.- Discussion.- Yersinia enterocolitica and Thyroid Disease.- Discussion.- In Vitro and In Vivo Effects of Cytokines.- Regulation of ICAM-1 Expression on Human Thyroid Follicular Cells.- Discussion.- Interleukin 6: A Pathogenic Factor in Autoimmune Thyroid Diseases?.- Discussion.- Endotoxins Do not Mimick the Effect of Interleukin-1 in Secondary Cultures of Human Thyroid Cells.- Blocking the Induction of HLA Class II Expression by Thyroid Epithelial Cells In Vitro.- Discussion.- Analysis of Intrathyroidal Cytokine Production in Thyroid Disease.- Discussion.- Lymphokine-Mediated Induction of HLA-DR Antigen Expression on Thyroid Follicular Cells In Vitro by Autologous Mononuclear Leukocytes and by Cytomegalovirus Infection.- Discussion.- Thyroid Dysfunction After High-Dose Interleukin-2 Therapy: An Update.- Discussion.- Human Recombinant Interleukin-ß Decreases Plasma Thyroid Hormone and TSH Levels in the Rat.- Discussion.- Thyroid Autoimmunity Induced by Interferon Therapy.- Discussion.- Effects of Interferon- ? and Interleukin-2 on Xenotransplanted Human Thyroid Tissue.- Discussion.- Closing Remarks.